Cisapride
Price | $1 |
Package | 1KG |
Min. Order: | 1G |
Supply Ability: | 100KG |
Update Time: | 2019-07-06 |
Product Details
Product Name: Cisapride | CAS No.: 81098-60-4 |
Min. Order: 1G | Purity: 98% |
Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
Cisapride Basic information |
Overview Mechanism of Action Pharmacokinetics Indications Adverse reactions Contraindication Precautions Drug Interactions |
Product Name: | Cisapride |
Synonyms: | benzamide,4-amino-5-chloro-n-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperi;monohydrate,cis-dinyl)-2-methoxy;prepulsid;propulsid;r51619;CISAPRIDE;CISAPRIDE HYDRATE;CISAPRIDE MONOHYDRATE |
CAS: | 81098-60-4 |
MF: | C23H29ClFN3O4 |
MW: | 465.95 |
EINECS: | 279-689-7 |
Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;Amines;Aromatics;Chiral Reagents;Heterocycles;API |
Mol File: | 81098-60-4.mol |
Cisapride Chemical Properties |
storage temp. | Store at RT |
solubility | DMSO: ~30 mg/mL |
form | solid |
color | white |
CAS DataBase Reference | 81098-60-4(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 41 |
Safety Statements | 26-39 |
WGK Germany | 2 |
RTECS | CU9372000 |
Hazardous Substances Data | 81098-60-4(Hazardous Substances Data) |
Cisapride Usage And Synthesis |
Overview | Cisapride is a gastrointestinal pro-motility drug, and was listed in the UK in 1988. It is a benzamide compound without anti-dopaminergic properties and does not have direct cholinergic properties. Its mechanism of action is different from that of metoclopramide and domperidone. It does not affect dopamine receptors, instead acts through acting with different serotonin receptors on the parietal plexus ending of the posterior wall of gastrointestinal organ, promoting the release of wall muscle acetylcholine (in quantity and time), further stimulating the entire digestive system organs and exerting an pro-motility effect. It does not affect the submucosal plexus, does not change the secretion of mucous membranes, belonging to a driving force drugs. This product can enhance the contraction and peristalsis of the human esophagus, stomach and duodenum, further improving the coordination of gastric antral duodenal region and preventing gastroesophageal and duodenal reflux. It can strengthen the emptying of the stomach and duodenum, and can promote the peristalsis of the large intestine and small intestine. It is mainly used for the treatment of gastrointestinal motility disorders, such as functional dyspepsia, gastroesophageal reflux disease, chronic constipation, bile reflux gastritis, neonatal vomiting and non-ulcer dyspepsia. Second, it can also be used for the treatment of non-gastrointestinal motility disorders, such as diabetic neurogenic bladder, gallbladder contraction disorders. |
Mechanism of Action | This product belongs to the whole gastrointestinal pro-motility drug. It can strengthen and coordinate gastrointestinal motility, further preventing food retention and reflux. Its mechanism of action is mainly through the selective promotion of the release of acetylcholine in the intestinal myenteric plexus postganglionic nerve, thereby enhancing gastrointestinal motility. Animal experiments confirmed that this product can accelerate the gastric motility, enhance the gastrointestinal - duodenal digestive activity, coordinate the action of gastric antrum - duodenum, small intestine and large intestine, and reduce intestinal movement time. In the human body, this product can enhance esophageal peristalsis, increase the tension of the lower esophageal sphincter to prevent the reflux of gastric contents into the esophagus and improve esophageal clearance; can enhance the contraction of stomach and duodenum and improve the gastric antrum – duodenum coordination. This effect can prevent duodenal - gastric reflux, promote gastric and duodenal emptying; promote small intestine and colon peristalsis. This product does not affect the gastrointestinal submucosal plexus, it does not change the secretion of gastrointestinal mucosa. At the same time because this product does not inhibit the activity of acetylcholinesterase, nor has dopamine receptor blocking effect, it does not increase gastric acid secretion; does not affect the level of plasma prolactin. Therefore, it basically has no central inhibitory effect. |
Pharmacokinetics | Oral administration leads to rapid absorption with plasma concentration reaching peak within 1 ~ 2h; protein binding rate: 98%; bioavailability: 40% to 50%; half-life:7 ~ 10h. It is subject to metabolism inside the body to demethylated cisapride. 90% is excreted through the urine with a small amount subjecting to milk excretion. |
Indications |
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Adverse reactions |
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Contraindication |
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Precautions |
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Drug Interactions |
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Chemical Properties | White Solid |
Uses | isoflavone used as a cholagogue and cathartic |
Uses | A Serotonin 5-HT4 receptro agonist. Used as a Gastroprokinetic |
Uses | Peristaltic stimulant;5-HT antagonist |
Definition | ChEBI: The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oeso hageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere. |
Biological Activity | 5-HT 4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT 4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com