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Postion:Product Catalog >API>Hormones and the Endocrine System>Thyroid hormone and antithyroid drugs>Methimazole
Methimazole
  • Methimazole

Methimazole

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Methimazole CAS No.: 60-56-0
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Methimazole Basic information
description Chemical properties Uses Production methods
Product Name: Methimazole
Synonyms: 1,3-dihydro-1-methyl-2h-imidazole-2-thion;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;1-metylo2merkaptoimidazolem;2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-;2H-Imidazole-2-thione,1,3-dihydro-1-methyl-
CAS: 60-56-0
MF: C4H6N2S
MW: 114.17
EINECS: 200-482-4
Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;M;API;TAPAZOLE;Other APIs;Medicine Intermediates;Pharmaceutical intermediates
Mol File: 60-56-0.mol
Article illustration
 
Methimazole Chemical Properties
Melting point  144-147 °C(lit.)
Boiling point  280 °C
density  1.176 (estimate)
refractive index  1.5000 (estimate)
Fp  280°C
storage temp.  Refrigerator
solubility  200g/l
form  Crystalline Powder
color  White to slightly cream or pale buff
Water Solubility  soluble
Merck  14,5971
BRN  108646
CAS DataBase Reference 60-56-0(CAS DataBase Reference)
NIST Chemistry Reference Methimazole(60-56-0)
EPA Substance Registry System 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-(60-56-0)
 
Safety Information
Hazard Codes  Xn
Risk Statements  43-62-63-22
Safety Statements  26-27-36-45-36/37
WGK Germany  3
RTECS  NI8615000
TSCA  Yes
HS Code  29332990
Hazardous Substances Data 60-56-0(Hazardous Substances Data)
Methimazole Usage And Synthesis
description Methimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone.
It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels.
It resembles propylthiouracil both in chemical structure and activity.
Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical properties leaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene.
Uses Carbimazole intermediates.
anti-thyroid drugs.
Production methods React amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal.
Chemical Properties White Solid
Uses Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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  • Since: 2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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