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Postion:Product Catalog >API>Hormones and the Endocrine System>Estrogen and progestin drugs>β-ESTRADIOL
β-ESTRADIOL
  • β-ESTRADIOL

β-ESTRADIOL

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: β-ESTRADIOL CAS No.: 50-28-2
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

β-ESTRADIOL Basic information
Indications and Usage Adverse reactions Contradictions
Product Name: β-ESTRADIOL
Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
CAS: 50-28-2
MF: C18H24O2
MW: 272.38
EINECS: 200-023-8
Product Categories: Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs;Inhibitors;powder or crystal
Mol File: 50-28-2.mol
Article illustration
 
β-ESTRADIOL Chemical Properties
Melting point  178-179 °C(lit.)
alpha  D25 +76 to +83° (dioxane)
Boiling point  355.44°C (rough estimate)
density  1.0708 (rough estimate)
refractive index  80.4 ° (C=1, Dioxane)
Fp  2℃
storage temp.  2-8°C
form  powder
color  White to off-white
Water Solubility  Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck  14,3703
BRN  1914275
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference 50-28-2(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System Estra-1,3,5(10)- triene-3,17-diol (17.beta.)-(50-28-2)
 
Safety Information
Hazard Codes  T,Xn,F
Risk Statements  60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements  53-22-36/37/39-45-36/37-26-16-36-20
RIDADR  2811
WGK Germany  3
RTECS  KG2975000
8-10
HazardClass  6.1
PackingGroup  III
HS Code  29372390
Hazardous Substances Data 50-28-2(Hazardous Substances Data)
β-ESTRADIOL Usage And Synthesis
Indications and Usage Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties White Crystalline Powder
Uses Potent mammalian estrogenic hormone produced by the ovary.
Uses Estradiol is the major estrogen secreted by the premenopausal ovary.
Definition ChEBI: The 17beta-isomer of estradiol.
Biological Activity Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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