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Postion:Product Catalog >API>Antiallergic drugs>Antihistamines>Diphenhydramine Hydrochloride
Diphenhydramine Hydrochloride
  • Diphenhydramine Hydrochloride
  • Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Diphenhydramine Hydrochloride CAS No.: 147-24-0
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Diphenhydramine Hydrochloride Basic information
Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications
Product Name: Diphenhydramine Hydrochloride
Synonyms: 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
EINECS: 205-687-2
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;BENADRIL;Other APIs;On the central nervous activity inhibition of sedative hypnotic effect;API;Pharmaceutical intermediates
Mol File: 147-24-0.mol
Article illustration
 
Diphenhydramine Hydrochloride Chemical Properties
Melting point  168-172 °C
Fp  9℃
storage temp.  Desiccate at RT
form  Crystalline Powder or Adhering Crystals
color  White
Water Solubility  1000 g/L
Sensitive  Light Sensitive
Merck  14,3309
Stability: Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
InChIKey PCHPORCSPXIHLZ-UHFFFAOYSA-N
CAS DataBase Reference 147-24-0(CAS DataBase Reference)
NIST Chemistry Reference diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride(147-24-0)
 
Safety Information
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7-24/25
RIDADR  2811
WGK Germany  3
RTECS  KR7000000
Toxicity LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)
 
Diphenhydramine Hydrochloride Usage And Synthesis
Description Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Article illustration
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.
Clinical Pharmacology Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.
Indications and Usage Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  2. Motion Sickness: For active treatment of motion sickness.
  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.
Drug overdose Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.
Contraindications
  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.
Chemical Properties white crystalline powder
Uses Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.
Uses antihistamine, sedative, treatment of allergic
Uses A histamine H1-receptor antagonist.
Uses H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic
Definition ChEBI: The hydrochloride salt of diphenhydramine.
General Description White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.
Air & Water Reactions Water soluble. Aqueous solutions are acidic.
Reactivity Profile N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.
Fire Hazard Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible.
Biological Activity H 1 receptor antagonist. Antihistamine.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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