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Fulvestrant Description:

FASLODEX is a medicine for postmenopausal women with hormone receptor-positive metastatic breast cancer with disease progression after antiestrogen therapy. When taken with palbociclib, it’s used to treat women with hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer whose disease has spread to other parts of the body (metastatic) with disease progression after hormonal therapy.

Regardless of whether it is used alone or with palbociclib, FASLODEX works in the same way: by targeting the estrogen receptor and impacting cancer growth.

Approved Uses for FASLODEX

FASLODEX is a prescription medicine used to treat:

When FASLODEX is used in combination with palbociclib, please also see the palbociclib Patient Information.

hormone receptor (HR)-positive breast cancer in women who have gone through menopause whose disease has spread after treatment with antiestrogen medicine, OR
HR-positive, human epidermal growth factor receptor 2 (HER2)‐negative breast cancer whose disease has spread to other parts of the body (metastatic) in combination with palbociclib in women with disease progression after hormonal therapy

Fulvestrant Application:

The estrogen receptor can play a role in the spread of estrogen receptor-positive metastatic breast cancer by:

Connecting with estrogen, which can send signals that may cause the spread of cancer
Sending signals throughout metastatic breast cancer cells that do not rely on estrogen to activate
Participating in the process tumor cells undergo as they divide, which is called the cell cycle

Because the estrogen receptor can support tumor cell division in several ways, you and your doctor may want to consider a treatment that targets the estrogen receptor—such as FASLODEX.

IMPORTANT SAFETY INFORMATION

Before receiving FASLODEX, tell your healthcare provider about all of your medical conditions, including if you:

1. FASLODEX is administered as a shot into the muscle of your buttock.
2. FASLODEX may cause injection site related nerve damage. Call your healthcare provider if you develop any of the following symptoms in your legs following a FASLODEX injection: numbness; tingling; weakness.

The most common side effects of FASLODEX include: injection site pain; nausea; muscle, joint, and bone pain; headache; tiredness; hot flashes; vomiting; loss of appetite; weakness; cough; shortness of breath, constipation; and increased liver enzymes.

You should not receive FASLODEX if you have had an allergic reaction to any of the ingredients in FASLODEX. Symptoms of an allergic reaction to FASLODEX may include: itching; swelling of your face, lips, tongue, or throat; trouble breathing

Have a low level of platelets in your blood or bleed easily. Especially tell your healthcare provider if you take a blood thinner medicine (anticoagulants)
Have liver problems
Are pregnant or plan to become pregnant, as FASLODEX can harm your unborn baby. Females who are able to become pregnant should use effective birth control during treatment with FASLODEX and for one year after the last dose. Tell your healthcare provider right away if you become pregnant or think you are pregnant while on FASLODEX

Are breast-feeding or plan to breast-feed. It is not known if FASLODEX passes into breast milk. Do not breast-feed during treatment with FASLODEX and for one year after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with FASLODEX. For more information, ask your healthcare provider or pharmacist.

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