4-O-Methyl honokiol NEW
| Price | $52 | $123 | $197 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 4-O-Methyl honokiol | CAS No.: 68592-15-4 |
| Purity: 99.31% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 4-O-Methyl honokiol |
| Description | 4-O-Methyl honokiol (4-O-Methylhonokiol) is a lignan-like compound obtained from Magnolia officinalis and Magnolia officinalis. It is a PPARγ agonist with antiangiogenic, anticancer, anti-inflammatory, and neuroprotective properties, and it can inhibit the activity of NF-κB, which can be used in cancer research. |
| Cell Research | Cells (5 × 10^4 cells per well) are plated onto 24-well plates. The cell growth inhibitory effect of 4-O-Methyl honokiol is evaluated in cells treated with 4-O-Methyl honokiol (0-30 μM) for 0-72 h, using an excluded trypan blue assay [1]. |
| Animal Research | Six-week-old male BALB/c athymic nude mice are used in the assay. SW620 and PC3 cells are injected s.c. (1 × 10^7 cells in 0.1 mL PBS per animal) into the lower right flanks of mice. After 20 days, when the tumors have reached an average volume of 300-400 mm3 or about 50 mm3, the tumor-bearing nude mice are i.p. injected with 4-O-Methyl honokiol (40 and 80 mg/kg dissolved in 0.1% DMSO) twice per week for 3 weeks. Cisplatin (10 mg/kg) is also i.p. injected once a week as a positive control. The group treated with 0.1% DMSO is designated as the control. The tumor volumes are measured with vernier calipers and calculated by the following formula: (A × B^2)/2, where A is the larger and B is the smaller of the two dimensions [1]. |
| In vitro | 4-O-Methyl honokiol (20 μM) increases the expression, transcription, DNA binding activities, and nuclear translocation of PPARγ in both prostate PC-3 and LNCap cells.[1] 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cell growth, causes G0/G1 phase arrest, and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knockdown of p21.[1] 4-O-methyl honokiol (0.5, 1, and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α, and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells.[2] |
| In vivo | 4-O-Methyl honokiol (40 or 80 mg/kg; i.p.; every day for 4 weeks) inhibits the growth of SW620 and PC3 tumors in the SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumor tissues.[1] 4-O-Methyl honokiol (0.5 or 1 mg/kg; every day for 3 weeks) significantly ameliorates LPS-induced memory impairment and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ1-42 accumulation and activates astrocytes and microglia in LPS-injected mice brains.[2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (285.35 mM), Sonication is recommended. |
| Keywords | 4-O-Methyl honokiol | 4OMethyl honokiol | 4 O Methyl honokiol |
| Inhibitors Related | Lidocaine | Daidzein | Diethylmaleate | Fenofibrate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Naringenin | Indole-3-carbinol | Diallyl disulfide | 2,3-Butanediol |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Nuclear Receptor Compound Library | Glycometabolism Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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