4-AMINO-2-FLUORO-N-METHYLBENZAMIDE NEW
Price | $35 |
Package | 1KG |
Min. Order: | 1KG |
Supply Ability: | 20 T each week |
Update Time: | 2023-08-18 |
Product Details
Product Name: 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE | CAS No.: 143782-23-4 |
EC-No.: 1592732-453-0 | Min. Order: 1KG |
Purity: 98%~99% | Supply Ability: 20 T each week |
Release date: 2023/08/18 |
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Product Name: | 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile |
Synonyms: | 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)-;3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile;4-cyano-3-trifluoromenthylphenylisothiocyanate;4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate;4-isothiocyananto-2-(trifluoromethyl) benzonitrile;4-Isothiocyanato-2;Isothiocyanato-2-(trifluoromethyl)benzonitrile |
CAS: | 143782-23-4 |
MF: | C9H3F3N2S |
MW: | 228.19 |
EINECS: | 1592732-453-0 |
Product Categories: | 143782-23-4 |
Mol File: | 143782-23-4.mol |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties |
Melting point | 39.0 to 43.0 °C |
Boiling point | 331℃ |
density | 1.31 |
Fp | 154℃ |
solubility | Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly) |
form | powder to lump |
color | White to Yellow to Green |
Stability: | Hygroscopic, Moisture sensitive |
InChI | InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H |
InChIKey | TYXKOMAQTWRDCR-UHFFFAOYSA-N |
SMILES | C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F |
CAS DataBase Reference | 143782-23-4 |
Safety Information |
HS Code | 2929100090 |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Usage And Synthesis |
Uses | 4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide. |
Uses | 4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents. |
Synthesis | 4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%). |
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials |
Preparation Products | 4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile-->Enzalutamide |
Company Profile Introduction
Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers.
Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries.
The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit.
Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.
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- Since: 2020-11-16
- Address: Room 202-9, Building 1, Evergrande Huafu, Dongying Road, Huaiyin District, Jinan City, Shandong Prov
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