3,3'-Diindolylmethane NEW
| Price | $39 | $53 | $81 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: 3,3'-Diindolylmethane | CAS No.: 1968-05-4 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | 3,3'-Diindolylmethane |
| 描述 | 3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent. |
| 細(xì)胞實(shí)驗(yàn) | The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference) |
| 體外活性 | 3,3'-Diindolylmethane is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. 3,3'-Diindolylmethane can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. 3,3'-Diindolylmethane alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1]. |
| 體內(nèi)活性 | Preliminary studies show 3,3'-Diindolylmethane is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of 3,3'-Diindolylmethane has radioprotection and mitigation properties in vivo. 3,3'-Diindolylmethane Activates ATM in Normal Tissues. 3,3'-Diindolylmethane can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 18 mg/mL (73.08 mM) DMSO : 50 mg/mL (203 mM), Sonication is recommended. |
| 關(guān)鍵字 | Inhibitor | 3,3' Diindolylmethane | HB-236 | Androgen Receptor | Autophagy | 3,3'-Diindolylmethane | HB236 | 3,3'Diindolylmethane | inhibit |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 植物來源化合物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36?Washington?Street, Wellesley?Hills
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