3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester NEW
Price | Get Latest Price |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 200kg |
Update Time: | 2023-11-01 |
Product Details
Product Name: 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester | CAS No.: 1809286-36-9 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 200kg | Release date: 2023/11/01 |
3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, ethyl ester
It is a chemical compound with the molecular formula C19H17NO4 and the molecular weight 323.34258 g/mol.
It is an intermediate for the synthesis of roxadustat, a drug for the treatment of anemia in chronic kidney disease (CKD) patients.
Roxadustat is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH), which stabilizes HIF and activates the transcription of erythropoietin (EPO) and other genes involved in erythropoiesis and iron metabolism .
Roxadustat has been approved in China for both dialysis-dependent and non-dialysis-dependent CKD patients, and is undergoing clinical trials in other countries.
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