20S Proteasome activator 1 NEW
| Price | $64 | $98 | $192 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: 20S Proteasome activator 1 | CAS No.: 2761578-18-9 |
| Purity: 99.68% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | 20S Proteasome activator 1 |
| 描述 | 20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases. |
| 體外活性 | At concentrations of 2.5-15 μM and a treatment duration of 45 minutes, 20S Proteasome activator 1 (compound 19) degrades 73% of α-synuclein at 10 μM and over 80% at 15 μM.[1] At concentrations of 5-15 μM and a 24-hour treatment period, 20S Proteasome activator 1 reduces A53T mutant α-synuclein by 25%. It also exhibits a dose-dependent reduction in the augmentation of α-synuclein in Hek-293T cells transiently transfected with an A53T mutant α-synuclein plasmid, achieving a 67% decrease at 15 μM.[1] |
| 存儲條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (101.43 mM), Sonication is recommended. |
| 相關(guān)產(chǎn)品 | Sitagliptin | Teneligliptin hydrobromide | Sitagliptin phosphate monohydrate | Anagliptin | Linagliptin | Aprotinin | Vildagliptin | Alloxan monohydrate | 4'-Hydroxychalcone | Bortezomib |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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