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Postion:Product Catalog >Pharmaceutical intermediates>Heterocyclic compound>Pyridine compound>Methylpyridine>2-Picolylamine
2-Picolylamine
  • 2-Picolylamine
  • 2-Picolylamine
  • 2-Picolylamine
  • 2-Picolylamine
  • 2-Picolylamine

2-Picolylamine NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 50000KG/month
Update Time: 2023-11-11

Product Details

Product Name: 2-Picolylamine CAS No.: 3731-51-9
EC-No.: 223-090-5 Min. Order: 1KG
Purity: 99% Supply Ability: 50000KG/month
Release date: 2023/11/11

CAS:3731-51-9
MF:C6H8N2
MW:108.14
EINECS:223-090-5
Product Categories:Heterocycle-Pyridine series;Pyridines derivates;Amines;bc0001
Mol File:3731-51-9.mol
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2-Picolylamine Chemical Properties
Melting point 20°C
Boiling point 82-85 °C12 mm Hg(lit.)
density 1.049 g/mL at 25 °C(lit.)
refractive index n20/D 1.578(lit.)
Fp 194 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
pkapK1: 2.31(+2);pK2: 8.79(+1) (25°C,μ=0.5)
form Liquid
color Clear colorless to yellow or orange
PH11-12 (100g/l, H2O, 20℃)
Water Solubility SOLUBLE
Sensitive Air Sensitive
BRN 108054
CAS DataBase Reference3731-51-9(CAS DataBase Reference)
NIST Chemistry Reference2-Pyridinemethanamine(3731-51-9)
EPA Substance Registry System2-Pyridinemethanamine (3731-51-9)
2-Picolylamine Usage And Synthesis
DescriptionIt is usually used as the intermediate or raw material in the organic synthesis and pharmaceutical synthesis. For example, this chemical can promote the Al(OTf)3-catalyzed aminolysis of 1,2-epoxides to produce β-Amino alcohols N-2'-pyridylmethyl in excellent yields.1 Moreover, this substance may function as the raw material to produce copper(Ⅱ) complexes with sulfonamides that act as the active chemical nucleases.2 In addition, by using this chemical as substrate, an efficient [2+3] cycloaddition approach has been developed for the synthesis of pyridyl-appended fullerene ligands.3 Besides, 2-picolylamine is chosen as the recognition group to get better selectivity for a rhodamine-based “turn-on” fluorescent probe for Fe3+ in aqueous solution.4
Reference
  1. Fringuelli, F.; Pizzo, F.; Tortoioli, S.; Vaccaro, L., Solvent-free Al(OTf)(3)-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine: A key step in the synthesis of ionic liquids. J. Org. Chem. 2004, 69, 7745-7747.

  2. Macias, B.; Villa, M. V.; Salgado, M.; Borras, J.; Gonzalez-Alvarez, M.; Sanz, F., Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. Inorg. Chim. Acta 2006, 359, 1465-1472.

  3. Troshin, P. A.; Peregudov, A. S.; Muhlbacher, D.; Lyubovskaya, R. N., An efficient 2+3 cycloaddition approach to the synthesis of pyridyl-appended fullerene ligands. Eur. J. Org. Chem. 2005, 3064-3074.

  4. Ji, S. Z.; Meng, X. M.; Ye, W. P.; Feng, Y.; Sheng, H. T.; Cai, Y. L.; Liu, J. S.; Zhu, X. F.; Guo, Q. X., A rhodamine-based "turn-on" fluorescent probe for Fe3+ in aqueous solution. Dalton Trans. 2014, 43, 1583-1588.

Chemical Propertiesclear colorless to yellow or orange liquid
Uses2-Picolylamine is a bihaptic amine that can be used:
  • As a key precursor to synthesize various ionic liquids through the formation of β-amino alcohols as intermediates.

  • As a chelating ligand for the synthesis of complexes such as zinc picolylamine complex and Cu(II) picolylamine complex.

  • To functionalize poly(styrene-co-maleic anhydride) (PSMA) resin to facilitate the adsorption of uranium from aqueous solution.


Uses2-Picolylamine may be used as a derivatization agent to enhance the sensitivity of carboxylic acids and short-chain fatty acids for their determination in biological samples by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ultra-high performance liquid chromatography (UHPLC), respectively.
DefinitionChEBI: 2-Pyridinemethanamine is a member of pyridines.
General Description2-Picolylamine, a bihaptic nucleophile, is a bidentate ligand that is generally utilized for the preparation of various multidentate ligands and the corresponding complexes.

Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Quantity(Kilograms)1 - 10000>10000
Est. Time(days)5To be negotiated

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Article illustrationCompany information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

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