2-Ketoglutaric acid Sodium NEW
| Price | $45 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: 2-Ketoglutaric acid Sodium | CAS No.: 22202-68-2 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | 2-Ketoglutaric acid Sodium |
| 描述 | 2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor. |
| 體外活性 | 2-Ketoglutaric acid Sodium is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. In particular, 2-Ketoglutaric acid Sodium can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in skeletal muscles. It has recently been shown that 2-Ketoglutaric acid Sodium can extend the lifespan of adult C. elegans by inhibiting ATP synthase and TOR. In combination with molecular oxygen, alpha-ketoglutarate is required for the hydroxylation of proline to hydroxyproline in the production of type I collagen. A recent study has shown that alpha-ketoglutarate promotes TH1 differentiation along with the depletion of glutamine thereby favouring Treg (regulatory T-cell) differentiation. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (297.48 mM) |
| 關鍵字 | alpha-Ketoglutaric acid sodium | α-Ketoglutaric acid sodium | intermediate | inhibit | TCA | precursor | 2-Ketoglutaric acid Sodium | carbon | skeleton | Endogenous Metabolite | Alpha-Ketoglutaric acid | Tyrosinase | 2 Ketoglutaric acid Sodium | 2-Ketoglutaric acid | 2Ketoglutaric acid Sodium | Inhibitor | a-Ketoglutaric acid sodium |
| 相關庫 | 天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 人內(nèi)源代謝化合物庫 | 腸道微生物代謝化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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