2-Deoxy-D-glucose NEW
| Price | $33 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 2-Deoxy-D-glucose | CAS No.: 154-17-6 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 2-Deoxy-D-glucose |
| Description | 2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. |
| Cell Research | 2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference) |
| In vitro | METHODS: Pancreatic cancer cells MIA PaCa2, BxPC-3, ASPC-1 and ovarian cancer cells OVCAR-3, HEY, SK-OV-3 were treated with 2-Deoxy-D-glucose (0.01-100 mM) for 48 h. Cell proliferation was detected using MTT. RESULTS: 2-Deoxy-D-glucose showed significant antiproliferative activity against tumor cells with IC50 values ranging from 1.45-13.34 mM. [1] METHODS: Triple-negative breast cancer cells Hs578T were treated with 2-Deoxy-D-glucose (15 mM) for 24 days, and cell motility was detected by Migration assay and Invasion assay. RESULTS: 2-Deoxy-D-glucose inhibited the migration and invasion of Hs578T cells. [2] |
| In vivo | METHODS: To study the effects on leukocyte subpopulation distribution and function, 2-Deoxy-D-glucose (500-1500 mg/kg) was injected intraperitoneally into BDF1 mice once or thrice. RESULTS: Blood glucose concentrations increased in a dose-dependent manner in mice injected with up to 1500 mg/kg of 2-Deoxy-D-glucose. Corticosterone levels, leukocyte counts in the spleen, and CD3+ cells in the thymus increased after one or three injections of 2-Deoxy-D-glucose up to 1500 mg/kg. 2-Deoxy-D-glucose administration induced dose-dependent changes in thymic and splenic cell distribution and function. [3] METHODS: To test the antitumor activity in vivo, 2-Deoxy-D-glucose (1000 mg/kg) was administered intraperitoneally to C57BL/6 mice bearing melanoma B16 once daily for eight days. RESULTS: 2-Deoxy-D-glucose significantly inhibited tumor growth, and TAMs showed a significant decrease in Arg, Fizz, CD206 and Vegf expression after 2-Deoxy-D-glucose treatment. [4] |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 100 mg/mL (609.16 mM) DMSO : 60 mg/mL (365.5 mM) |
| Keywords | HSV | Hexokinase | Apoptosis | 2 Deoxy D glucose | Herpes simplex virus | 2-Deoxy-D-glucose | inhibit | NSC-15193 | 2DeoxyDglucose | Inhibitor | NSC15193 | 2-DG |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Saccharide and Glycoside Natural Product Library | Microbial Natural Product Library | Inhibitor Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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