2-Bromopyridine NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-16 |
Product Details
| Product Name: 2-Bromopyridine | CAS No.: 109-04-6 |
| EC-No.: 203-641-6 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/16 |
| CAS: | 109-04-6 |
| MF: | C5H4BrN |
| MW: | 158 |
| EINECS: | 203-641-6 |
| Product Categories: | alkyl bromide;C5Heterocyclic Building Blocks;Bromopyridines;Halopyridines;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridines derivates;bc0001;109-04-6 |
| Mol File: | 109-04-6.mol |
 | |
| 2-Bromopyridine Chemical Properties |
| Melting point | 193°C |
| Boiling point | 192-194 °C (lit.) |
| density | 1.657 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 130 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 20g/l |
| pka | pK1: 0.71(+1) (25°C) |
| form | Liquid |
| color | Clear colorless to pale brown |
| Water Solubility | Slightly miscible with water. |
| BRN | 105789 |
| Stability: | Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides. |
| InChIKey | IMRWILPUOVGIMU-UHFFFAOYSA-N |
| LogP | 1.42 |
| CAS DataBase Reference | 109-04-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2-bromo-(109-04-6) |
| EPA Substance Registry System | Pyridine, 2-bromo- (109-04-6) |
| 2-Bromopyridine Usage And Synthesis |
| Chemical Properties | light yellow oily or dark red liquid. miscible with ethanol, ether, benzene and pyridine, still soluble in water. |
| Uses | 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist. |
| Application | 2-Bromopyridine can be used as: A building block in the formation of C?N bond by various cross coupling reactions. A reactant in Negishi cross-coupling reaction with aryl halides catalyzed by palladium. A reactant in the synthesis of 2′-pyridyldifluoroacetate with ethyl bromodifluoroacetate in presence of copper as a catalyst. |
| Preparation | 2-Bromopyridine is synthesized from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (over 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise in a salt bath under freezing, and the rate of addition is to control the reaction temperature below -5°C appropriate. After adding, add sodium nitrite aqueous solution dropwise, control the reaction temperature to be below 0°C, stir for 20-30min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, and the 88°C-94°C/3333Pa fraction was collected to obtain the finished product of 2-bromopyridine with a yield of 83.8%. |
| Definition | ChEBI: 2-bromopyridine is a monobromopyridine. |
| Reactions | 2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, which is a versatile reagent.Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group. |
| Flammability and Explosibility | Flammable |
| Purification Methods | Dry 2-bromopyridine over KOH for several days, then distil it from CaO under reduced pressure, and taking the middle fraction. [Beilstein 20/5 V 422.] |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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Japan
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- Address: Building A, Enjoy city, Zhongshan East Road, Shijiazhuang city, Hebei province
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