Description of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid from Wuhan Fortuna Chemical Co.,Ltd

Specifications(COA) of Chemical raw material 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid / DOTA CAS 60239-18-1

Introduction of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, commonly abbreviated as DOTA, is a macrocyclic compound that is widely used in the field of chemistry and medicine, particularly in the development of contrast agents for magnetic resonance imaging (MRI) and in radiopharmaceuticals for diagnostic imaging and therapy.

Structure and Properties:

Chemical Formula: C16H28N4O8

Molecular Weight: 404.42 g/mol

Structure: DOTA consists of a 12-membered ring containing four nitrogen atoms (tetraaza) and four acetic acid groups attached to the nitrogen atoms. The macrocyclic ring provides a stable framework for binding metal ions.

Applications:

MRI Contrast Agents: DOTA is used to chelate (bind) gadolinium ions (Gd3?) to form gadolinium-DOTA complexes. These complexes are highly stable and are used as contrast agents in MRI to enhance the quality of the images by altering the magnetic properties of nearby water molecules.

Radiopharmaceuticals: DOTA can also chelate various radioactive metal ions, such as yttrium-90 (Y-90), lutetium-177 (Lu-177), and indium-111 (In-111). These radiolabeled DOTA complexes are used in targeted radiotherapy and diagnostic imaging. For example, DOTA-conjugated peptides can target specific receptors on cancer cells, allowing for precise delivery of the radioactive isotope to the tumor site.

Research and Development: DOTA and its derivatives are used in various research applications, including the development of new diagnostic and therapeutic agents, due to their ability to form stable complexes with a wide range of metal ions.

Advantages:

High Stability: The macrocyclic structure of DOTA provides exceptional stability to the metal complexes, reducing the risk of metal ion release in the body.

Versatility: DOTA can chelate a variety of metal ions, making it useful for multiple applications in medical imaging and therapy.

Biocompatibility: DOTA and its metal complexes are generally well-tolerated in biological systems, making them suitable for clinical use.

In summary, 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a versatile and highly stable chelating agent used extensively in medical imaging and radiopharmaceuticals. Its ability to form strong complexes with metal ions makes it invaluable in enhancing the efficacy and safety of diagnostic and therapeutic procedures.

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