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Postion:Product Catalog >API>Antineoplastic agents>Tinib Antineoplastic drugs>Dasatinib
Dasatinib
  • Dasatinib
  • Dasatinib
  • Dasatinib
  • Dasatinib
  • Dasatinib

Dasatinib

Price Get Latest Price
Package 25KG
Min. Order: 2KG
Supply Ability: 20tons
Update Time: 2024-11-01

Product Details

Product Name: Dasatinib CAS No.: 302962-49-8
EC-No.: 801-607-0 Min. Order: 2KG
Purity: USP26, EP VI / GMP DMF Supply Ability: 20tons
Release date: 2024/11/01

Product Information

Product name

Dasatinib

Molecular Formula

C22H28CIN7O3S

Molecular Weight

506.02

CAS No.

302962-49-8

Quality Standard

USP26, EP, medical grade

Appearance

White powder

COA of Dasatinib

ITEMS

SPECIFICATION

RESULTS

IDENTIFICATION

POSITIVE REACTION

CONFORMS

Water

≤1.5%

0.9%

LOSS ON DRYING

≤0.1%

0.03%

RESIDUE ON IGNITION

≤0.1%

0.02%

CHROMATOGRAPHIC PURITY

RANITIDINE RELATED COMPOUND B≤0.5%

ANY OTHER IMPURITY≤0.3%

THE SUM OF ALL IMPURITIES≤1.0%

CONFORMS

CONFORMS

CONFORMS

ORGANIC VOLATILE IMPURITIES

AS STIPULATED

CONFORMS

ASSAY

(ON DRY SUBSTANCE)

98.0%~102.0%

99.8%

CONCLUSION

CONFORMS TO in house


Usage

Function of Dasatinib

Dasatinib (DASA tin IB), used for all treatment stages (chronic phase, accelerated phase) Stage, lymphoid cell blast crisis and myeloid blast crisis) adult patients. At the same time, the FDA also approved Dasatinib through normal procedures to treat Philadelphia chromosome-positive acute lymphoblastic leukemia adult patients who are resistant or intolerant to other therapies.

Dasatinib inhibits BCR-ABL kinase and SRC family kinases as well as many other selective oncogenic kinases, including c-KIT, ephrin (EPH) receptor kinase and PDGFβ receptor. Dasatinib is a potent, subnanomolar BCR-ABL kinase inhibitor with a strong activity at a concentration of 0.6 to 0.8 nmol. It can be combined with the inactive and active configurations of the BCR-ABL enzyme.

In vitro studies, dasatinib is active in leukemia cell lines expressing various imatinib-sensitive and drug-resistant diseases. The results of these non-clinical studies indicate that dasatinib can overcome imatinib resistance caused by: BCR-ABL overexpression, BCR-ABL kinase region mutations, kinases including SRC family kinases (LYN, HCK) in Over-expression of other signaling pathways within, as well as multidrug resistance genes. In addition, dasatinib can inhibit SRC family kinases at this nanomolar concentration

In an in vivo experiment conducted using the murine CML model alone, dasatinib prevented the progression of chronic phase CML to the acute phase, while prolonging tumor-bearing mice (derived from patient CML cell lines growing in different locations, including the central Nervous system)



Article illustration

Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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