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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs>Lopinavir
Lopinavir
  • Lopinavir
  • Lopinavir
  • Lopinavir
  • Lopinavir
  • Lopinavir

Lopinavir

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 0.1Kg/Bag
Supply Ability: 20tons
Update Time: 2024-11-08

Product Details

Product Name: Lopinavir CAS No.: 192725-17-0
Min. Order: 0.1Kg/Bag Purity: USP
Supply Ability: 20tons Release date: 2024/11/08

Product Information

Product name

Lopinavir

CAS No.

192725-17-0

Molecular Formula

C37H48N4O5

Molecular Weight

628.801

Quality Standard

99% up, USP42, Medicine Grade

Appearance

White powder

COA of Lopinavir

TEST

SPECIFICATION

RESULTS

Description

White  powder

Complies

Identification

IR

Complies


HPLC

Complies 

Heavy metal

≤10ppm

5ppm

Pb

≤3ppm

1.5ppm

Hg

≤0.1ppm

0.05ppm

Cd

≤1ppm

0.2ppm

Loss on drying

≤0.5%

0.12

Residue on lgnition

≤0.1%

0.03

Single impurity

≤0.5%

0.12

Total impurity

≤1.0%

0.29

Total bacteria

≤1000cfu/g

<1000

Yeast and Mould

≤100 cfu/g

<000

E.coli/25g

Absent

Absent

Salmonella/25g

Absent

Absent

Assay

≥99.0%

99.4%

Conclusion

Conforms with USP/EP standards


Usage

Function of Lipinavir

Lipinavir is used in combination with other antiretroviral drugs to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children over 2 years old.

Lopinavir is an HIV protease inhibitor, which can block the division of Gag-Pol polyprotein, resulting in the production of immature, non-infectious virus particles; ritonavir is a kind of HIV-1 and HIV- 2 Peptidomimetic inhibitors of aspartyl protease activity. By inhibiting HIV protease, the enzyme cannot process the precursor of Gag-Pol polyprotein, resulting in the formation of immature HIV particles, which prevents the start of a new infection cycle. Ritonavir can inhibit CYP3A-mediated metabolism of lopinavir, resulting in a higher concentration of lopinavir.

Antiviral activity of Lopinavir: In vitro antiviral drug activity studies in combination with lopinavir have shown that the combination of lopinavir and nelfinavir will increase the antagonistic effect, and it can be compared with amprenavir, atazanavir and indinavir The combined application of Vivi, Saquinavir and Telanavir will increase the synergy. The EC50 value of lopinavir for three different HIV-2 virus strains is between 12~180nM (0.008~113 μg/mL).



Article illustration


Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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