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Postion:Product Catalog >API>Hormones and the Endocrine System>Pancreatic hormone and blood sugar regulation>Gliclazide
Gliclazide
  • Gliclazide

Gliclazide

Price $190
Package 1Kg/Bag
Min. Order: 1KG
Supply Ability: 100KG
Update Time: 2024-08-30

Product Details

Product Name: Gliclazide CAS No.: 21187-98-4
EC-No.: 244-260-5 Min. Order: 1KG
Purity: 99% Supply Ability: 100KG
Release date: 2024/08/30

Gliclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.

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  • Since: 2008-05-08
  • Address: No.10,the 4th road of High-tech zone, Baoji City, Shaan’xi province, Mainland China
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