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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiseptics & Disinfectants Drugs>1,3-Dibromo-5,5-dimethylhydantoin
1,3-Dibromo-5,5-dimethylhydantoin
  • 1,3-Dibromo-5,5-dimethylhydantoin
  • 1,3-Dibromo-5,5-dimethylhydantoin

1,3-Dibromo-5,5-dimethylhydantoin NEW

Price $6 $0.2
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: 1,3-Dibromo-5,5-dimethylhydantoin CAS No.: 77-48-5
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information

Names

Name1,3-Dibromo-5,5-dimethylhydantoin
SynonymMore Synonyms

 1,3-Dibromo-5,5-dimethylhydantoin Biological Activity

Description1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker
Target

Alkyl-Chain

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density2.2±0.1 g/cm3
Boiling Point250.2±23.0 °C at 760 mmHg
Melting Point197-199 °C (dec.)(lit.)
Molecular FormulaC5H6Br2N2O2
Molecular Weight285.921
Flash Point105.1±22.6 °C
Exact Mass283.879578
PSA40.62000
LogP1.68
Vapour Pressure0.0±0.5 mmHg at 25°C
Index of Refraction1.622

 MSDS

1,3-Dibromo-5,5-dimethylhydantoin MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • MU0686000

  • CHEMICAL NAME :

  • Hydantoin, 1,3-dibromo-5,5-dimethyl-

  • CAS REGISTRY NUMBER :

  • 77-48-5

  • BEILSTEIN REFERENCE NO. :

  • 0146024

  • LAST UPDATED :

  • 199710

  • DATA ITEMS CITED :

  • 8

  • MOLECULAR FORMULA :

  • C5-H6-Br2-N2-O2

  • MOLECULAR WEIGHT :

  • 285.95

  • WISWESSER LINE NOTATION :

  • T5NVNV EHJ AE CE E1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 250 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971

  • TYPE OF TEST :

  • LCLo - Lowest published lethal concentration

  • ROUTE OF EXPOSURE :

  • Inhalation

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 29 gm/m3/1H

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0281-0382

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Administration onto the skin

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 20 gm/kg

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

  • REFERENCE :

  • EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0581-0382 ** OTHER MULTIPLE DOSE TOXICITY DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 52 mg/kg/17W-I

  • TOXIC EFFECTS :

  • Endocrine - evidence of thyroid hypofunction

  • REFERENCE :

  • GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83854 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated)

 Safety Information

SymbolArticle illustration Article illustration Article illustration Article illustration
GHS03, GHS05, GHS06, GHS09
Signal WordDanger
Hazard StatementsH272-H301-H314-H317-H410
Precautionary StatementsMissing Phrase - N15.00950417-P210-P220-P280-P305 + P351 + P338-P370 + P378
Personal Protective EquipmentEyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard CodesC:Corrosive
Risk PhrasesR22;R34;R50;R8
Safety PhrasesS17-S26-S36/37/39-S45-S60-S61
RIDADRUN 3087 5.1/PG 2
WGK Germany3
RTECSMU0686000
Packaging GroupII
Hazard Class5.1
HS Code29332100

 Synthetic Route

Total: 1 Page
Article illustration

5,5-Dimethylimi...

CAS#:77-71-4

~99%

Article illustration

1,3-Dibromo-5,5...

CAS#:77-48-5

Literature: ALBEMARLE CORPORATION Patent: EP1250045 B1, 2003 ;
Article illustration

1,3-Dichloro-5,...

CAS#:118-52-5

Article illustration

5,5-Dimethylimi...

CAS#:77-71-4

~%

Article illustration

1,3-Dibromo-5,5...

CAS#:77-48-5

Literature: US2868787 , ;
Article illustration

Sodium cyanide

CAS#:143-33-9

Article illustration

Acetone

CAS#:67-64-1

~%

Article illustration

1,3-Dibromo-5,5...

CAS#:77-48-5

Literature: Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 41, p. 153

 Precursor & DownStream

Precursor  4


  • Article illustration CAS#:77-71-4
    5,5-Dimethylimi...

  • Article illustration CAS#:118-52-5
    1,3-Dichloro-5,...

  • Article illustration CAS#:143-33-9
    Sodium cyanide

  • Article illustration CAS#:67-64-1
    Acetone

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:27973-29-1
    1,6-Dibromopyrene

  • Article illustration CAS#:38303-35-4
    1,8-Dibromopyrene

  • Article illustration CAS#:108-94-1
    Cyclohexanone

  • Article illustration CAS#:663954-33-4
    1-N,1-N,6-N,6-N...

 Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621









Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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