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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride NEW
| Price | $30 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 2000kg |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | CAS No.: 111974-74-4 |
| Min. Order: 1kg | Purity: 98% |
| Supply Ability: 2000kg | Release date: 2024/11/01 |
| 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties |
| Melting point | 180-184°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO, Methanol, Distilled Water |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H |
| InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N |
| SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl |
| CAS DataBase Reference | 111974-74-4(CAS DataBase Reference) |
| 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Usage And Synthesis |
| Description | Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4 |
| Chemical Properties | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid |
| Uses | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic |
| Uses | N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic. |
| References | 1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709 |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company Profile Introduction
Hebei Hongtan Technology Co., Ltd. was established in 2018. In 2019, the Ministry of Foreign Trade was established. The team has 10 members and has invested $300,000 in product development. Our goal is to make everyone can use inexpensive beauty products, the company's products have passed the CE certification, the main products are slimming peptide, anti-wrinkle peptide, melanin peptide, etc., reliable quality, inexpensive.
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China- Since: 2021-09-01
- Address: Room 1306, Unit 04, Building 1, Tatan International Trade City, 118 Shengli South Street, Qiaoxi Dis
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