1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride
Price | Get Latest Price | ||
Package | 1kg | 5kg | 10kg |
Min. Order: | 1kg |
Supply Ability: | 1000 |
Update Time: | 2025-01-10 |
Product Details
Product Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride | CAS No.: 903576-44-3 |
Min. Order: 1kg | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/10 |
Product Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride
Synonyms: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride;BF 2649;Ciproxidine;Pitolisant (hydrochloride);1-[3-[3-(4-Chlorophenyl)propoxy]propyl]piperidine monohydrochloride;Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, hydrochloride;Ciproxidine BF2649;PITOLISANT;CIPROXIDINE BF2649
CAS: 903576-44-3
MF: C17H26ClNO.HCl
MW: 332
Pitolisant hydrochloride, a first-in-class inverse agonist of the histamine H3 receptor, was approved in the EU for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy with or without cataplexy. The drug, which was developed by Bioprojet and has orphan drug designation in the EU and US, enhances wakefulness by increasing histaminergic neuron activity. With once daily oral administration in the morning, patients taking pitolisant exhibited significantly reduced EDS versus placebo but not versus modafinil. Plasma levels of the drug are reduced at the end of the day such that its waking effect is minimized at night (plasma t1/2 10-12 h). Several articles have been published detailing the discovery of pitolisant.
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- Address: Room 02-31, 13 / F, Building 9, Guannan Fuxing Medical Park Phase II, No.58, Guanggu Avenue, East La