(±)-Zanubrutinib NEW
| Price | $42 | $98 | $156 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: (±)-Zanubrutinib | CAS No.: 1633350-06-7 |
| Purity: 98.19% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | (±)-Zanubrutinib |
| 描述 | (±)-Zanubrutinib ((±)-BGB-3111) is a potent, orally available Bruton's tyrosine kinase (Btk) inhibitor, exhibiting superior oral bioavailability, higher exposure, and more complete target inhibition. |
| 體外活性 | In both biochemical and cellular assays, (±)-Zanubrutinib exhibits nanomolar Btk inhibition activity. Compared to ibrutinib, (±)-Zanubrutinib shows significantly more restricted off-target activities against a panel of kinases, including ITK. In various MCL and DLBCL cell lines, (±)-Zanubrutinib inhibits BCR aggregation-triggered Btk autophosphorylation, blocks downstream PLC-γ2 signaling, and effectively inhibits cell proliferation[1]. |
| 體內(nèi)活性 | (±)-Zanubrutinib exhibits dose-dependent anti-tumor properties in mice with REC-1 MCL xenografts, regardless of whether the xenografts are engrafted subcutaneously or through systemic injection via the tail vein. A preliminary 14-day toxicity study in rats indicates that (±)-Zanubrutinib is exceptionally well-tolerated, with a maximally tolerated dose (MTD) remaining undetermined at dosages up to 250mg/kg/day[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (106.03 mM) Ethanol : 9.0 mg/mL (19.1 mM) |
| 關(guān)鍵字 | BGB-3111 | Zanubrutinib | BGB 3111 | BGB3111 |
| 相關(guān)產(chǎn)品 | CP-547632 | Ibrutinib | IBT6A | Orelabrutinib |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | 共價(jià)抑制劑庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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