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Postion:Product Catalog >API>Circulatory system drugs>Antihypertensive drugs> Sodium nitroprusside dihydrate
Sodium nitroprusside dihydrate
  • Sodium nitroprusside dihydrate
  • Sodium nitroprusside dihydrate

Sodium nitroprusside dihydrate NEW

Price $5 $0.1
Package 1KG 1000KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-05

Product Details

Product Name: Sodium nitroprusside dihydrate CAS No.: 13755-38-9
Min. Order: 1KG Purity: 98%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/05
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Name: Tina

 1. Materials information

Names

Namesodium nitroprusside dihydrate
SynonymMore Synonyms

 Sodium nitroprusside dihydrate Biological Activity

DescriptionNitroprusside disodium dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.Target: OthersNitroprusside disodium dihydrate is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate [1]. Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells [2]. Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats [3].
Related Catalog
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Cardiovascular Disease
References

[1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

[2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

[3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.

 Chemical & Physical Properties

Density1.72
Molecular FormulaC5H4FeN6Na2O3
Molecular Weight297.948
Exact Mass297.948975
PSA166.84000
LogP0.16990
Storage conditionStore at RT.
Water Solubility400g/l (slow decomposition)

 MSDS

Sodium nitroprusside dihydrate MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • LJ8925000

  • CHEMICAL NAME :

  • Ferrate(2-), pentacyanonitrosyl-, disodium, dihydrate

  • CAS REGISTRY NUMBER :

  • 13755-38-9

  • LAST UPDATED :

  • 199707

  • DATA ITEMS CITED :

  • 17

  • MOLECULAR FORMULA :

  • C5-Fe-N6-O.2Na.2H2-O

  • MOLECULAR WEIGHT :

  • 297.98

  • WISWESSER LINE NOTATION :

  • NA2 FE-CN5-NO &QH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Human - child

  • DOSE/DURATION :

  • 11700 ug/kg/60H-I

  • TOXIC EFFECTS :

  • Sense Organs and Special Senses (Eye) - effect, not otherwise specified

  • REFERENCE :

  • CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 31,380,1992

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 20 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,883,1980

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 9300 ug/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,1092,1979

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 9 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 9500 ug/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 6 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 80 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 1 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 50 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - cat

  • DOSE/DURATION :

  • 1 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 40 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 4800 ug/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rabbit

  • DOSE/DURATION :

  • 1800 ug/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,1092,1979

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Bird - pigeon

  • DOSE/DURATION :

  • 10 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Amphibian - frog

  • DOSE/DURATION :

  • 40 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6152 No. of Facilities: 76 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1925 (estimated) No. of Female Employees: 1358 (estimated)

 Safety Information

SymbolArticle illustration
GHS06
Signal WordDanger
Hazard StatementsH301
Precautionary StatementsP301 + P310
Personal Protective EquipmentEyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard CodesT: Toxic;
Risk PhrasesR25
Safety Phrases45-36/37/39-22
RIDADRUN 3288 6
WGK Germany3
RTECSLJ8925000
Packaging GroupIII
Hazard Class6.1
HS Code2837199090

 Customs

HS Code2837199090


2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621







Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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