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Postion:Product Catalog >Biochemical Engineering>Natural Products> Genistein
	Genistein
  • 	Genistein
  • 	Genistein

Genistein NEW

Price $8 $5 $1
Package 1kg 25kg 100kg
Min. Order: 1kg
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-05

Product Details

Product Name: Genistein CAS No.: 446-72-0
Min. Order: 1kg Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/05
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
NAME: Sun

1. Product information

 Names

Namegenistein
SynonymMore Synonyms

 Genistein Biological Activity

DescriptionGenistein, a soy isoflavone, is a multiple tyrosine kinases inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
Related Catalog
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Natural Products >> Flavonoids
Research Areas >> Cancer
Target

EGFR:0.6 μM (IC50, Cell Assay)

In VitroGenistein inhibits serum-stimulated growth of MCF-7 and T47D ER+ cells with IC50 values of 7.6 and 8.7 μg/mL by dye exclusion, respectively, and 8.7 and 10.6 μg/mL by [3H]thymidmne incorporation, respectively. These values are similar to the IC50 values of 9.4 and 7 μg/mL for MCF-7 and T47D ER+ cells, respectively, obtained with the MTT assay. Additionally, Genistein at concentrations up to 20 μg/mL does not alter MTT mitochondrial reduction when compared to control cells in an 8 h incubation period. Furthermore, neither biochanin A or daidzein are found to interfere with the MTT assay at IC50 concentrations. Therefore, the MTT assay is valid for determining growth inhibition by Genistein at concentrations under 20 μg/mL in the systems studied[1].
In VivoIn the present study, the effective dose of morphine caused a significant decrease in testis weight of mice compared to Saline group (p=0.00). Moreover, testis weight are significantly increase in treated animals with Genistein and Genistein plus morphine in all doses in comparison with morphine group (p=0.028). Morphine caused a significant decrease in the testosterone, LH and FSH hormones compared to saline group (p=0.00). In addition, the testosterone, LH and FSH hormones increased significantly in Genistein (p<0.05) and Genistein plus morphine in all groups administration compared to morphine group (p=0.024)[2]. Bisphenol A (BPA) treatment alone and combined with Genistein had no significant effect on the protein expression of LC3II and PPARα in liver of STD- or HFD-fed rats (P>0.05; P>0.05). Significant decreasing of the protein expression of PPARγ in liver is observed when Genistein is added to rats, compared to either HFD group or HFD-BPA group[3].
Cell AssayThe IC50 values for Genistein are determined by the MTT assay. Briefly, the MTT assay is a colorimetric assay that is based on the ability of living but not dead cells to reduce a tetrazolium-based compound to a blue formazan product. The formazan crystals are solubilized in DMSO, and the absorbance is measured at 540 nm. The absorbance at 540 nm is proportional to the number of viable cells. The lC50 values obtained with the MTT assay are compared with the lC50 values obtained by counting viable cells using trypan blue dye exclusion and by tritiated thymidine incorporation into DNA[1].
Animal AdminMice[2] Balb/c male mice are used. Genistein is administered as follows: On days 1-30, Genistein once daily, interaperitoneally injecting. Morphine plus Genistein is administered as follows: On days 1-30, Genistein once daily plus morphine, interaperitoneally injecting (17, 18). The same volume of saline is administered. Mice are randomly divided into 8 groups (n=6). 1) Normal saline group (1 mL DW/daily); 2) Morphine treated group; 3) Genistein 1 mg/kg treated group; 4) Genistein 2 mg/kg treated group 5) Genistein 4 mg/kg treated group; 6) Morphine plus Genistein 1 mg/kg treated group; 7) Morphine plus Genistein 2 mg/kg treated group; 8) Morphine plus Genistein 4 mg/kg treated group. Rats[3] Male 8-week-old Wistar rats (150-180g) are used. After one week acclimation, all rats are randomly divided into 8 groups with 10 rats per group and treated for 35 weeks as follows: (1) STD group is fed with rodent standard chow diet (STD); (2) STD-BPA group is fed with STD and administered with BPA (50 μg/kg/day); (3) STD-(BPA+G) group is fed with STD and administered with BPA (50 μg/kg/day) plus Genistein (10 mg/kg/day); (4) STD-G group is fed with STD and administered with Genistein (10 mg/kg/day); (5) HFD group received high-fat diet (HFD); (6) HFD-BPA group is fed with HFD and administered with BPA (50 μg/kg/day); (7) STD-(BPA+G) group is fed with HFD and administered with BPA (50 μg/kg/day) plus Genistein (10 mg/kg/day); (8) HFD-G group is fed with HFD and administrated with Genistein (10 mg/kg/day). All the male genitors are treated for 35 weeks consecutively. The details of BPA (50 μg/kg/day) and Genistein (10 mg/kg/day) treatment methods have been described previously: BPA is dissolved in corn oil and diluted with three stock solutions (20, 40, 80, and 120 μg/mL).
References

[1]. Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7(10):1345-51.

[2]. Jalili C, et al. Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice. Int J Reprod Biomed (Yazd). 2016 Feb;14(2):95-102.

[3]. Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11(5):e0155352.

 Chemical & Physical Properties

Density1.5±0.1 g/cm3
Boiling Point555.5±50.0 °C at 760 mmHg
Melting Point297-298 °C
Molecular FormulaC15H10O5
Molecular Weight270.237
Flash Point217.1±23.6 °C
Exact Mass270.052826
PSA90.90000
LogP2.96
Vapour Pressure0.0±1.6 mmHg at 25°C
Index of Refraction1.732
Storage condition?20°C
StabilityLight Sensitive
Water Solubilityinsoluble

 MSDS

Genistein MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • NR2392000

  • CHEMICAL NAME :

  • Isoflavone, 4',5,7-trihydroxy-

  • CAS REGISTRY NUMBER :

  • 446-72-0

  • BEILSTEIN REFERENCE NO. :

  • 0263823

  • LAST UPDATED :

  • 199801

  • DATA ITEMS CITED :

  • 12

  • MOLECULAR FORMULA :

  • C15-H10-O5

  • MOLECULAR WEIGHT :

  • 270.25

  • WISWESSER LINE NOTATION :

  • T66 BO EVT&J CR DQ& IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD - Lethal dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 125 mg/kg

  • SEX/DURATION :

  • female 16-20 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - urogenital system

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 625 mg/kg

  • SEX/DURATION :

  • female 16-20 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 1680 mg/kg

  • SEX/DURATION :

  • female 21 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - other effects

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 13200 mg/kg

  • SEX/DURATION :

  • male 22 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 18600 mg/kg

  • SEX/DURATION :

  • female 31 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

  • TYPE OF TEST :

  • Mutation in mammalian somatic cells

  • TEST SYSTEM :

  • Rodent - hamster Lung

  • DOSE/DURATION :

  • 25 umol/L

  • REFERENCE :

  • FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,605,1997

 Safety Information

SymbolArticle illustration
GHS07
Signal WordWarning
Hazard StatementsH302
Precautionary StatementsP301 + P312 + P330
Personal Protective EquipmentEyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi: Irritant;
Risk PhrasesR36/38
Safety PhrasesS26-S24/25-S22
RIDADRNONH for all modes of transport
WGK Germany3
RTECSNR2392000
HS Code2932999099

 Synthetic Route

Previous 1/12 Next
Article illustration

α-(4&rsqu...

15485-65-1

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Sodium formate

141-53-7

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Propanoyl chlor...

79-03-8

~94%

Article illustration

Genistein

446-72-0

Literature: ROCHE VITAMINS AG Patent: WO2004/9576 A2, 2004 ; Location in patent: Page 17 ;
Article illustration

Formic Acid

64-18-6

Article illustration

α-(4&rsqu...

15485-65-1

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Propionic anhyd...

123-62-6

~86%

Article illustration

Genistein

446-72-0

Literature: ROCHE VITAMINS AG Patent: WO2004/9576 A2, 2004 ; Location in patent: Page 20 ;
Article illustration

α-(4&rsqu...

15485-65-1

Article illustration

Sodium formate

141-53-7

Article illustration

2-Methylpropano...

79-30-1

~90%

Article illustration

Genistein

446-72-0

Literature: ROCHE VITAMINS AG Patent: WO2004/9576 A2, 2004 ; Location in patent: Page 23 ;

 Precursor & DownStream

Precursor  10

Previous 1/3 Next

  • Article illustration CAS#:15485-65-1
    α-(4’-Hydroxyph...

  • Article illustration CAS#:141-53-7
    Sodium formate

  • Article illustration CAS#:79-03-8
    Propanoyl chloride

  • Article illustration CAS#:64-18-6
    Formic Acid

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:34086-51-6
    7-O-Methylbioch...

  • Article illustration CAS#:1162-82-9
    GENISTEIN TRIME...

  • Article illustration CAS#:552-59-0
    Prunetin

  • Article illustration CAS#:13539-27-0
    8'-HYDROXYGENISTEIN

 Customs

HS Code2932999099
Summary2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

5-18-04-00594 (Beilstein Handbook Reference)
5,7,4'-trihydroxyisoflavone
4',5,7-trihydroxyisoflavone
Genistein
GeniVida
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
prunetol
EINECS 207-174-9
genisteol
Bonistein
NPI 031L
MFCD00016952
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Genestein
sophoricol
GLYCITEN




2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address : sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137





Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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