(±)-Carnitine chloride NEW
| Price | $29 |
| Package | 10g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (±)-Carnitine chloride | CAS No.: 461-05-2 |
| Purity: 99.56% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (±)-Carnitine chloride |
| Description | (±)-Carnitine chloride (Monocamin) is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. |
| Kinase Assay | Mitochondria (0.6 mg protein/mL) are incubated in 2.5 mM Hepes (pH7.4) containing 225 mM mannitol, 75 mM sucrose and 100 μM ethylene glycol tetraacetic acid (EGTA) with or without 5 mM L-carnitine at 25°C. To measure oxygen uptake, 10 min after inorganic phosphate (Pi) 4 mM are added, the mitochondria are treated with palmitoyl-CoA (50 μM) and then ADP is added (200 μM). Oligomycin (5 μM) and rotenone (10 μM) are added 3-4 min after the ADP treatment. HPG (0-10 mM), which can specifically inhibit carnitine palmitoyl transferase (CPT)-I activity in the mitochondria, is added in the Hepes medium before incubation of the mitochondria[1]. |
| In vitro | L-carnitine primarily facilitates the translocation of long-chain fatty acids across the inner mitochondrial membrane by transforming acyl-CoA into acyl-carnitine via carnitine palmitoyl transferase (CPT)-I activation. This acyl-carnitine is then converted back into acyl-CoA within the mitochondrial matrix by CPT-II. L-carnitine's introduction enhances palmitoyl-CoA-induced mitochondrial respiration, further accelerated by ADP, showcasing a concentration-dependent effect that reaches saturation at 5 mM L-carnitine[1]. Additionally, L-carnitine pre-treatment enhances Nrf2 nuclear translocation, its DNA binding activity, and heme oxygenase-1 (HO-1) expression in Water2-treated HL7702 cells, providing protection against Water2-induced cell damage through Akt-mediated Nrf2 signaling pathway activation[2]. |
| In vivo | L-carnitine has been shown to modulate the ubiquitin-proteasome pathway and enhance IGF-1 levels in animal studies. Its administration over two weeks can mitigate muscle mass and fiber size reduction in the soleus muscle caused by hindlimb suspension. Additionally, L-carnitine inhibits atrogin-1 mRNA expression, crucial for preventing muscle atrophy. Concurrent L-carnitine treatment also reduces renal fibrosis—associated with lowered plasma TGF-β1 levels—and addresses the enhanced oxidative and inflammatory states observed in L-NAME treated groups, alongside promoting PPAR-γ expression. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 37 mg/mL (187.2 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (227.66 mM) |
| Keywords | DL-Carnitine Chloride | inhibit | DL-Carnitine | Reactive Oxygen Species | Carnitine Chloride | (±)-Carnitine | (±)Carnitine chloride | Inhibitor | (±) Carnitine chloride |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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