5-DEMETHYLNOBILETIN NEW

Price	$6	$5	$1
Package	1KG	25KG	100KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-29

Product Details

Product Name: 5-DEMETHYLNOBILETIN	CAS No.: 2174-59-6
Min. Order: 1KG	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/29
Lead time: In stock	Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express	Origin: Manufacturer
Name: Sun

1. Product information

Name	2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
Synonym	More Synonyms

Description	5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Neurological Disease
Target	IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1]
References	[1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.

Density	1.304±0.06 g/cm3
Boiling Point	601.4±55.0 °C at 760 mmHg
Melting Point	145-146 oC
Molecular Formula	C₂₀H₂₀O₈
Molecular Weight	388.368
Flash Point	213.9±25.0 °C
Exact Mass	388.115814
PSA	96.59000
LogP	2.10
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.583
Storage condition	2-8C
Water Solubility	Practically insoluble (0.058 g/L) (25 oC)

HS Code	2914509090

Nobiletin

478-01-3

~85%

5-O-Demethylnob...

2174-59-6

Literature: Bioorganic and Medicinal Chemistry, , vol. 19, # 23 p. 7085 - 7092

1-(2-hydroxy-3,...

654083-34-8

5-O-Demethylnob...

2174-59-6

Literature: Yakugaku Zasshi, , vol. 60, p. 614; engl. Ref. S. 246 Chem.Abstr., , p. 7964

veratroyl chlor...

3535-37-3

5-O-Demethylnob...

2174-59-6

Literature: Yakugaku Zasshi, , vol. 60, p. 614; engl. Ref. S. 246 Chem.Abstr., , p. 7964

Precursor 10	Previous 1/3 Next
CAS#:478-01-3 Nobiletin CAS#:654083-34-8 1-(2-hydroxy-3,... CAS#:3535-37-3 veratroyl chloride CAS#:333347-81-2 (1H-benzo[d][1,...
DownStream 1
CAS#:478-01-3 Nobiletin

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-

2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one

5-hydroxy-6,7,8,3',4'-pentamethoxyflavone

Demethylnobiletin

5-O-Demethylnobiletin

5-hydroxy-3',4',6,7,8-pentamethoxyflavone

5-Demethylnobiletin

5-desmethylnobeletin

5-desmethylnobiletin

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

Article illustration

3. Shipping

Article illustration

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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