(S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
| 中文名稱 | (S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸 |
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| 中文同義詞 | (S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸;(S)-()-6-羥基-2,5,7,8-四甲基色烷-2-羧酸;化合物 T12816;(S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸;(S)-6-羥基-2,5,7,8-四甲基苯并二氫吡喃-2-羧酸 |
| 英文名稱 | (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID |
| 英文同義詞 | (S)-(-)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C;(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2α-carboxylic acid;(S)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid;(S)-6-Hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid;(2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid;(S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%;(S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID |
| CAS號 | 53174-06-4 |
| 分子式 | C14H18O4 |
| 分子量 | 250.29 |
| EINECS號 | |
| 相關(guān)類別 | 雜環(huán)化合物;Benzopyrans;Chiral Building Blocks;Heterocyclic Building Blocks |
| Mol文件 | 53174-06-4.mol |
| 結(jié)構(gòu)式 |  |
(S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸 性質(zhì)
| 熔點(diǎn) | 160 °C (dec.) (lit.) |
|---|---|
| 沸點(diǎn) | 450.3±45.0 °C(Predicted) |
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 乙腈（少量溶解）、氯仿（少量，超聲處理）、甲醇（少量溶解） |
| 酸度系數(shù)(pKa) | 3.35±0.20(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至淺棕色 |
| 旋光性 (optical activity) | [α]26/D 65°, c = 1.2 in ethanol |
The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH.
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