N-(4-溴苯基)-4-苯基噻唑-2-胺
| 中文名稱 | N-(4-溴苯基)-4-苯基噻唑-2-胺 |
|---|---|
| 中文同義詞 | N-(4-溴苯基)-4-苯基噻唑-2-胺;化合物RCGD423;RCGD 423,GP130調(diào)制器;化合物RCGD423,10 MM DMSO 溶液 |
| 英文名稱 | 4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine |
| 英文同義詞 | 4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine;RCGD423;2-Thiazolamine, N-(4-bromophenyl)-4-phenyl-;RCGD 432;N-(4-Bromophenyl)-4-phenylthiazol-2-amine;RCGD423,inhibit,RCGD 423,Inhibitor,Interleukin Related,RCGD-423;Regulator of cartilage growth and differentiation (RCGD) 423;RC D423 |
| CAS號(hào) | 108237-91-8 |
| 分子式 | C15H11BrN2S |
| 分子量 | 331.23 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 108237-91-8.mol |
| 結(jié)構(gòu)式 |  |
N-(4-溴苯基)-4-苯基噻唑-2-胺 性質(zhì)
| 儲(chǔ)存條件 | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| 溶解度 | DMSO:34.0(最大濃度 mg/mL);102.6(最大濃度 mM) 乙醇:34.0(最大濃度 mg/mL);102.6(最大濃度 mM) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
RCGD-423 是 Glycoprotein 130 (gp130, IL6ST, IL6-beta, CD130) 信號(hào)調(diào)節(jié)劑，可調(diào)節(jié)軟骨生長(zhǎng)和分化。
|
IL6-beta
|
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 10mM * 1mLin DMSO | 525元 |
| 2025/02/08 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 5mg | 720元 |