| Company Name: |
Shanghai ChuangYan Chemical Technology Co., Ltd. Gold
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| Tel: |
021-11111111 11111111111 |
| Email: |
546919421@qq.com |
| Products Intro: |
Product Name:4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CAS:929915-58-2
Purity:95% HPLC Package:1g,5g,10g,25g,50g,100g
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:DG-051
CAS:929915-58-2
Purity:98% Package:1G;10G;100G Remarks:DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor, the enzyme that catalyzes the rate-determining step in the synthesis of LTB4. HDG-051 does not show any inhibitory a
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- DG 051 (HCl salt)
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- $1.00 / 1KG
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2019-07-06
- CAS:929915-58-2
- Min. Order: 1KG
- Purity: 96%
- Supply Ability: 500kg
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| | DG 051 (HCl salt) Basic information |
| Product Name: | DG 051 (HCl salt) | | Synonyms: | DG 051 (HCl salt);4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride;DG051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;DG051
(DG-051;DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051 | | CAS: | 929915-58-2 | | MF: | C21H25Cl2NO4 | | MW: | 426.3335 | | EINECS: | | | Product Categories: | | | Mol File: | 929915-58-2.mol |  |
| | DG 051 (HCl salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml | | form | Solid | | color | White to light yellow |
| | DG 051 (HCl salt) Usage And Synthesis |
| Description | DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG. | | Uses | (2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers. |
| | DG 051 (HCl salt) Preparation Products And Raw materials |
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