Related articles - What is Euphporbia factor L3?
- Euphorbia factor L3 (EFL3, chemically named 5,15-Diacetyl-3-benzoyllathyrol) was obtained as colorless crystal from dichlorome....
- Feb 13，2020
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| Product Name: | DIACETYL BENZOYL LATHYROL | | Synonyms: | DIACETYL BENZOYL LATHYROL;(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-4a,8-Bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-4H-cyclopenta[a]cyclopropa[f]cycloundecen-4-one;5,15-Diacetyl-3-benzoyllathyrol;Euphorbia factor L3;Phytoclear EL-1;Lathyrol-3,15-diacetate-5-benzoate;Eupho;Euphporbia factor L3 | | CAS: | 218916-52-0 | | MF: | C31H38O7 | | MW: | 522.63 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 218916-52-0.mol |  |
| | DIACETYL BENZOYL LATHYROL Chemical Properties |
| Boiling point | 595.5±50.0 °C(Predicted) | | density | 1.19 | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | color | White to off-white |
| | DIACETYL BENZOYL LATHYROL Usage And Synthesis |
| Cytotoxicity | EFL3 of lathyrane diterpenoids showed potent cytotoxicity to A549 cells. Furthermore, EFL3 induced apoptosis of A549 cells through mitochondrial pathway with involvement of loss of ΔΨm, release of cytochrome c.
The cytotoxicity of EFL3 was determined by an MTT assay to evaluate its antitumor activity. The results showed that EFL3 inhibited cell proliferation in a concentration-dependent manner in A549 cells after 72 h treatment. The IC50 of EFL3 for A549 cells was 34.04 ± 3.99 μM. The data suggested that EFL3 exhibited potent cytotoxicity towards these cells.
The results showed that EFL3 showed more potent cytotoxicity to A549 cellsMolecules 2011, 16 3225 than EFL1 (P < 0.01).
| | Uses | Lathyrol-3,15-diacetate-5-benzoate could induce apoptosis in lung cancer A549 cells through the mitochondrial pathway including the loss of mitochondrial potential and release of cytochrome c. | | Definition | ChEBI: Diacetyl benzoyl lathyrol is a diterpenoid. |
| | DIACETYL BENZOYL LATHYROL Preparation Products And Raw materials |
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