2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide manufacturers
- PFI-90
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- $34.00 / 25mg
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2024-11-04
- CAS:53995-62-3
- Min. Order:
- Purity: 99.5%
- Supply Ability: 10g
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| | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Basic information |
| Product Name: | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide | | Synonyms: | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide;PFI-90;N'-(Pyridin-2-yl)picolinohydrazide;antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit;N'-(Pyridin-2-yl)picolinohydrazide;N'-pyridin-2-ylpyridine-2-carbohydrazide | | CAS: | 53995-62-3 | | MF: | C11H10N4O | | MW: | 214.22 | | EINECS: | | | Product Categories: | | | Mol File: | 53995-62-3.mol |  |
| | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Chemical Properties |
| Melting point | 128-131 °C | | Boiling point | 359.4±17.0 °C(Predicted) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 10.14±0.23(Predicted) | | color | Light yellow to yellow |
| | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Usage And Synthesis |
| Biological Activity | PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. | | References | [1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1. |
| | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Preparation Products And Raw materials |
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