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PREGNENOLONE MONOSULFATE SODIUM SALT

PREGNENOLONE MONOSULFATE SODIUM SALT

中文名稱PREGNENOLONE MONOSULFATE SODIUM SALT
中文同義詞孕烯醇酮 硫酸鈉鹽;未標(biāo)記的孕烯醇硫酸鹽;孕烯醇硫酸鹽 (20,21-13C2,99%;化合物 T16574;化合物 PREGNENOLONE MONOSULFATE SODIUM SALT
英文名稱PREGNENOLONE SULFATE SODIUM SALT
英文同義詞PREGNENOLONE SULFATE SODIUM;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT;3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT;3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT
CAS號(hào)1852-38-6
分子式C21H31NaO5S
分子量418.52
EINECS號(hào)
相關(guān)類別Steroids
Mol文件1852-38-6.mol
結(jié)構(gòu)式PREGNENOLONE MONOSULFATE SODIUM SALT 結(jié)構(gòu)式

PREGNENOLONE MONOSULFATE SODIUM SALT 性質(zhì)

熔點(diǎn)192 °C(lit.)
儲(chǔ)存條件Store at -20°C
溶解度溶于甲醇和水的混溶液中,1.93mg/mL
形態(tài)結(jié)晶固體
顏色白色至米白色

PREGNENOLONE MONOSULFATE SODIUM SALT 用途與合成方法

Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) 是一種功能強(qiáng)大的神經(jīng)甾體,是包括甾體酮在內(nèi)的各種甾體激素的主要前體。Pregnenolone monosulfate sodium salt 是大麻素 CB1 受體的信號(hào)傳導(dǎo)特異性抑制劑,抑制由 CB1 受體介導(dǎo)的四氫大麻酚 (THC) 的作用。Pregnenolone monosulfate sodium salt 可以保護(hù)大腦免受大麻毒性的侵襲。

CB1

Human Endogenous Metabolite

CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.

安全信息

WGK Germany3

MSDS信息

提供商 語(yǔ)言
英文
更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-110189PREGNENOLONE MONOSULFATE SODIUM SALT
Pregnenolone monosulfate sodium salt
1852-38-65mg550元
2024/08/19HY-110189PREGNENOLONE MONOSULFATE SODIUM SALT
Pregnenolone monosulfate sodium salt
1852-38-610mg880元

PREGNENOLONE MONOSULFATE SODIUM SALT 上下游產(chǎn)品信息

"PREGNENOLONE MONOSULFATE SODIUM SALT"相關(guān)產(chǎn)品信息
Pregnenolone-[20,21-13C2,16,16-d2]sulfatesodiumsalt(Solution) 金剛石粉 Pregnanolone-[d5] Pregnenolone-[20,21-13C2,16,16-D2]sulfatesodiumsalt SodiumPregnenolone-17α,21,21,21-d4Sulfate 妊娠烯醇酮-D4 Pregnenolone-2,2,4,4-d4 Pregnenolone-[20,21-13C2,16,16-D2] 孕烯醇酮甲醚-[D4] Pregnenolone-[20,21-13C2,16,16-d2] 孕烯醇酮
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