| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BRD0476
CAS:1314958-91-2
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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BRD 0476 manufacturers
- BRD0476
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- $2500.00 / 100mg
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2024-10-28
- CAS:1314958-91-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | BRD 0476 Basic information |
| Product Name: | BRD 0476 | | Synonyms: | BRD 0476;ML 187;ML187;ML-187;1,4-Benzodioxin-6-sulfonamide, 2,3-dihydro-N-methyl-N-[[(2R,3R)-3,4,5,6-tetrahydro-5-[(1S)-2-hydroxy-1-methylethyl]-3-methyl-10-[[(1-naphthalenylamino)carbonyl]amino]-6-oxo-2H-1,5-benzoxazocin-2-yl]methyl]- | | CAS: | 1314958-91-2 | | MF: | C35H38N4O8S | | MW: | 674.76 | | EINECS: | | | Product Categories: | | | Mol File: | 1314958-91-2.mol |  |
| | BRD 0476 Chemical Properties |
| density | 1.364±0.06 g/cm3(Predicted) | | pka | 13.37±0.60(Predicted) |
| | BRD 0476 Usage And Synthesis |
| Description | BRD0476, also known as ML187, is a novel suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. However, unlike common JAK-STAT pathway inhibitors, BRD0476 inhibits JAK-STAT signaling without suppressing the kinase activity of any JAK. BRD0476 suppresses cytokine-induced β-cell apoptosis. | | Definition | ChEBI: 1-[(2R,3R)-2-[[2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl(methyl)amino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-3-(1-naphthalenyl)urea is a member of naphthalenes. |
| | BRD 0476 Preparation Products And Raw materials |
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