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Pazopanib-d6

Pazopanib-d6 Suppliers list
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:Pazopanib-d6
CAS:1219592-01-4
Package:1mg;438USD
Company Name: ChemStrong Scientific Co.,Ltd  
Tel: 0755-0755-66853366 13670046396
Email: sales@chem-strong.com
Products Intro: Product Name:Pazopanib-d6
CAS:1219592-01-4
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
Company Name: Artis Biotech Co. Ltd.  
Tel: 0575-18780151478 18582380095
Email: sales@artisbio.com
Products Intro: Product Name:Pazopanib-d6
CAS:1219592-01-4
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Email: sales@glpbio.cn
Products Intro: Product Name:Pazopanib-d6
CAS:1219592-01-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:Pazopanib-d6
CAS:1219592-01-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g

Pazopanib-d6 manufacturers

  • Pazopanib-d6
  • Pazopanib-d6 pictures
  • $438.00 / 1mg
  • 2024-11-19
  • CAS:1219592-01-4
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
Pazopanib-d6 Basic information
Product Name:Pazopanib-d6
Synonyms:Pazopanib-d6;2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide;2H6]-Pazopanib;2-methyl-5-({4-[(2H?)methyl[2-(2H?)methyl-3-methyl-2H-indazol-6-yl]amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide
CAS:1219592-01-4
MF:C21H23N7O2S
MW:437.52
EINECS:
Product Categories:
Mol File:1219592-01-4.mol
Pazopanib-d6 Structure
Pazopanib-d6 Chemical Properties
storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMSO: 16 mg/ml
form A solid
color White to off-white
Safety Information
MSDS Information
Pazopanib-d6 Usage And Synthesis
DescriptionPazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay).1 It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.2 It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.
References1. Kumar, R., Knick, V.B., Rudolph, S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol. Cancer Ther. 6(7),2012-2021(2007).
2. Podar, K., Tonon, G., Satler, M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma Proc. Natl. Acad. Sci. USA 103(5),19478-19483(2006).
Pazopanib-d6 Preparation Products And Raw materials
Tag:Pazopanib-d6(1219592-01-4) Related Product Information
1,3-DiMethyl-6-aMino-1H-indazole 3-AMINO-4-METHYLBENZENESULFONAMIDE N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 5-Amino-2-methylbenzenesulfonamide 2-Ethyl-5-nitrobenzenamine ,98% 3-Methyl-6-nitroindazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 4(1H)-Pyrimidinone, 2-chloro- (9CI) 1,3-Dimethyl-6-nitro-1H-indazole 3-Methyl-6-nitro-2H-indazole 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) Pazopanib 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Related Compound 2 2-Methyl-5-nitrobenzenesulfonamide 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide