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| | 2-Propylpiperidine Basic information |
| Product Name: | 2-Propylpiperidine | | Synonyms: | 2-PRIOPYLPIPERIDINE;2-PROPYLPIPERIDINE;2-N-PROPYLPIPERIDINE;(2R)-2-Propylpiperidine;(R)-2-Propylpiperidine;DL-CONIINE;CONIINE;CONIINE, DL- | | CAS: | 3238-60-6 | | MF: | C8H17N | | MW: | 127.23 | | EINECS: | 221-801-3 | | Product Categories: | Alkaloids | | Mol File: | 3238-60-6.mol |  |
| | 2-Propylpiperidine Chemical Properties |
| Melting point | -2℃ | | Boiling point | 56-60 °C(Press: 13 Torr) | | density | 0.85 g/mL at 25 °C(lit.) | | storage temp. | Sealed in dry,2-8°C | | pka | pK1:11.24(+1) (25°C,μ=0.5) | | form | liquid | | color | , clear colorless to yellow-green | | CAS DataBase Reference | 3238-60-6(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 23/24/25-40 | | Safety Statements | 22-36/37/39-45 | | RIDADR | UN 2810 6.1/PG 2 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Toxicity | Piperidine alkaloid obtained
from poison hemlock, Conium maculatum. Alkaline, steam
volatile liquid (b.p. 167_x0003_C), mousy odor. Darkens and polymerizes
in air. It can be reduced at high temperature with HI
to n-octane and oxidized to pyridine-1-carboxylic acid. The
hydrochloride is used as an antispasmodic. |
| | 2-Propylpiperidine Usage And Synthesis |
| Chemical Properties | Colorless liquid; darkens on exposure tolight and air; polymerizes; boils at 166°C(330.8°F); melts at -2°C (28.4°F); alkaline, pKa 3.1; density 0.845 at 20°C (68°F);slightly soluble in water and chloroform,readily soluble in most organic solvents. | | Uses | Coniine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited. | | Synthesis Reference(s) | Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9 | | Health Hazard | Coniine is a highly toxic alkaloid. Thetoxic symptoms from ingestion are weakness,drowsiness, nausea, vomiting, muscle contraction, and labored breathing. A high dosecan cause convulsions, cyanosis, asphyxia,and death. Chronic ingestion of coniine produced adverse reproductive effects and spe cific developmental abnormalities in cattles.LD50 value, oral (mice): 100 mg/kg. |
| | 2-Propylpiperidine Preparation Products And Raw materials |
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