- 1,5-Isoquinolinediol
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- $38.00 / 25mg
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2024-11-17
- CAS:5154-02-9
- Min. Order:
- Purity: 99.43%
- Supply Ability: 10g
- 1,5-Isoquinolinediol
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- $0.00 / 1KG
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2024-11-14
- CAS:5154-02-9
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | 1,5-ISOQUINOLINEDIOL Basic information |
| Product Name: | 1,5-ISOQUINOLINEDIOL | | Synonyms: | 1,5-ISOQUINOLINEDIOL;1,5-DIHYDROXYISOQUINOLINE;5-HYDROXYISOCARBOSTYRIL;5-HYDROXY-1(2H)-ISOQUINOLINE;5-HYDROXY-1(2H)-ISOQUINOLINONE;1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE);1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ;5-Hydroxyisoquinoline-1(2H)-one | | CAS: | 5154-02-9 | | MF: | C9H7NO2 | | MW: | 161.16 | | EINECS: | 637-104-6 | | Product Categories: | Aromatics;Inhibitors | | Mol File: | 5154-02-9.mol |  |
| | 1,5-ISOQUINOLINEDIOL Chemical Properties |
| Melting point | 270-275 °C | | Boiling point | 287.44°C (rough estimate) | | density | 1.2480 (rough estimate) | | refractive index | 1.5050 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO: >36 mg/mL | | form | solid | | pka | 8.52±0.20(Predicted) | | color | off-white | | CAS DataBase Reference | 5154-02-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29337900 |
| | 1,5-ISOQUINOLINEDIOL Usage And Synthesis |
| Description | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals. | | Chemical Properties | white to off-white solid | | Uses | Reagent used in the preparation of PARP inhibitor. | | Uses | 1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor. | | Definition | ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups. | | General Description | A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells. | | Biochem/physiol Actions | Cell permeable: yes | | storage | +4°C |
| | 1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials |
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