丙炔基-四聚乙二醇-對(duì)甲苯磺酸酯
| 中文名稱 | 丙炔基-四聚乙二醇-對(duì)甲苯磺酸酯 |
|---|---|
| 中文同義詞 | 丙炔基-四聚乙二醇-對(duì)甲苯磺酸酯;丙炔基-四聚乙二醇-TOS;丙炔-五聚乙二醇-對(duì)甲苯磺酸酯;3,6,9,12-四氧雜十五碳-14-炔-1-基 4-甲基苯磺酸酯;丙炔基-PEG4-對(duì)甲苯磺酸酯;丙炔基-PEG5-對(duì)甲苯磺酸酯;丙炔-五聚乙二醇-甲苯磺酸酯;炔丙基-四聚乙二醇-對(duì)甲苯磺酸酯 |
| 英文名稱 | Propargyl-PEG4-Tos |
| 英文同義詞 | Propargyl-PEG4-Tos;Propargyl-PEG5-Tos;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate);3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate |
| CAS號(hào) | 875770-32-4 |
| 分子式 | C18H26O7S |
| 分子量 | 386.46 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 875770-32-4.mol |
| 結(jié)構(gòu)式 |  |
丙炔基-四聚乙二醇-對(duì)甲苯磺酸酯 性質(zhì)
| 沸點(diǎn) | 498.1±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.177±0.06 g/cm3(Predicted) |
| 形態(tài) | 液體 |
| 顏色 | 無(wú)色至淺黃 |
Propargyl-PEG4-Tos 是一種 PROTAC linker，屬于 PEG 類。Propargyl-PEG4-Tos 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-Tos 是一種可降解 (cleavable) 的 ADC linker，用于抗體偶聯(lián)藥物 (ADCs) 的合成。
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PEGs
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Cleavable
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.