LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
中文名稱 | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID |
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中文同義詞 | 化合物 T15818;化合物 LY367385 HYDROCHLORIDE;化合物 LY367385 |
英文名稱 | LY 367385 |
英文同義詞 | (S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID;LY 367385;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid;(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid;(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid;LY-367385 hydrochloride;(R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid;LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID |
CAS號 | 198419-91-9 |
分子式 | C10H11NO4 |
分子量 | 209.2 |
EINECS號 | |
相關(guān)類別 | Glutamate |
Mol文件 | 198419-91-9.mol |
結(jié)構(gòu)式 |
LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 性質(zhì)
儲存條件 | Desiccate at RT |
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溶解度 | H2O:>10mg/mL |
形態(tài) | 粉末 |
顏色 | 白色至類白色 |
mGluR1a 8.8 μM (IC 50 ) |
LY367385 combined with N-methyl-D-aspartate (NMDA) during the toxic pulse attenuates neuronal degeneration in a concentration-dependent fashion, with a maximal reduction of NMDA toxicity ranging from 40 to 60%. LY367385 shows greater efficacy than LY367366 and neither of these compounds influenced neuronal viability per se. LY367385 shows potent neuroprotective effects, with causing a 50% reduction in (S)-3,5-Dihydroxyphenylglycine (DHPG) potentiation at a concentration of 10 nM. Under experimental conditions at higher concentrations of antagonist, LY367385 a completely antagonized the amplification of NMDA toxicity by DHPG.
LY367385 has been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice, LY367385 produces a rapid, transient suppression of sound-induced clonic seizures ED50 = 12 nM, i.c.v., 5 min). In lethargic mice, LY367385 significantly reduces the incidence of spontaneous spike and wave discharges on the electroencephalogram, from 30 to >150 min after the administration of LY367385, 250 nM, i.c.v.
In genetically epilepsy prone rats, LY367385 reduces sound-induced clonic seizures. LY367385, 160 nM bilaterally, fully suppresses clonic seizures after 2-4 h.
安全信息
WGK Germany | 3 |
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更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2024/11/08 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY367385 hydrochloride | 198419-91-9 | 5mg | 850元 |
2024/11/08 | HY-107515A | LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY367385 hydrochloride | 198419-91-9 | 10mM * 1mLin DMSO | 940元 |