成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID

中文名稱LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
中文同義詞化合物 T15818;化合物 LY367385 HYDROCHLORIDE;化合物 LY367385
英文名稱LY 367385
英文同義詞(S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID;LY 367385;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid;(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid;(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid;LY-367385 hydrochloride;(R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid;LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
CAS號198419-91-9
分子式C10H11NO4
分子量209.2
EINECS號
相關(guān)類別Glutamate
Mol文件198419-91-9.mol
結(jié)構(gòu)式LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 結(jié)構(gòu)式

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 性質(zhì)

儲存條件Desiccate at RT
溶解度H2O:>10mg/mL
形態(tài)粉末
顏色白色至類白色

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 用途與合成方法

LY367385 是一種高效且選擇性的 mGluR1a 拮抗劑,抑制喹喹啉誘導(dǎo)的磷酸肌醇水解的 IC50 值為 8.8 μM,而對 mGlu5a 的 IC50 值大于 100 μM。LY367385 具有神經(jīng)保護,抗驚厥和抗癲癇作用。

mGluR1a

8.8 μM (IC 50 )

LY367385 combined with N-methyl-D-aspartate (NMDA) during the toxic pulse attenuates neuronal degeneration in a concentration-dependent fashion, with a maximal reduction of NMDA toxicity ranging from 40 to 60%. LY367385 shows greater efficacy than LY367366 and neither of these compounds influenced neuronal viability per se. LY367385 shows potent neuroprotective effects, with causing a 50% reduction in (S)-3,5-Dihydroxyphenylglycine (DHPG) potentiation at a concentration of 10 nM. Under experimental conditions at higher concentrations of antagonist, LY367385 a completely antagonized the amplification of NMDA toxicity by DHPG.

LY367385 has been administered intracerebroventricularly (i.c.v.) to DBA/2 mice and lethargic mice (lh/lh), and focally into the inferior colliculus of genetically epilepsy prone rats (GEPR). In DBA/2 mice, LY367385 produces a rapid, transient suppression of sound-induced clonic seizures ED50 = 12 nM, i.c.v., 5 min). In lethargic mice, LY367385 significantly reduces the incidence of spontaneous spike and wave discharges on the electroencephalogram, from 30 to >150 min after the administration of LY367385, 250 nM, i.c.v.
In genetically epilepsy prone rats, LY367385 reduces sound-induced clonic seizures. LY367385, 160 nM bilaterally, fully suppresses clonic seizures after 2-4 h.

安全信息

WGK Germany3

MSDS信息

更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-107515ALY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
LY367385 hydrochloride
198419-91-95mg850元
2024/11/08HY-107515ALY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID
LY367385 hydrochloride
198419-91-910mM * 1mLin DMSO940元

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID 上下游產(chǎn)品信息

"LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID"相關(guān)產(chǎn)品信息
N,N-二乙基苯甲酰胺 升對酞酸
主頁 | 企業(yè)會員服務(wù) | 廣告業(yè)務(wù) | 聯(lián)系我們 | 舊版入口 | 中文MSDS | CAS Index | 常用化學(xué)品CAS列表 | 化工產(chǎn)品目錄 | 新產(chǎn)品列表 | 評選活動 | HS海關(guān)編碼 | MSDS查詢 | 化工站點

Copyright © 2016-2023 ChemicalBook 版權(quán)所有  京ICP備07040585號  京公海網(wǎng)安備11010802032676號  

互聯(lián)網(wǎng)增值電信業(yè)務(wù)經(jīng)營許可證:京ICP證150597號  互聯(lián)網(wǎng)藥品信息服務(wù)資格證編號(京)-非經(jīng)營性-2015-0073  信息系統(tǒng)安全等級保護備案證明(三級)  營業(yè)執(zhí)照公示

根據(jù)相關(guān)法律法規(guī)和本站規(guī)定,單位或個人購買相關(guān)危險物品應(yīng)取得有效的資質(zhì)、資格條件。
參考《應(yīng)急管理部等多部門關(guān)于加強互聯(lián)網(wǎng)銷售危險化學(xué)品安全管理的通知 (應(yīng)急〔2022〕119號)》《互聯(lián)網(wǎng)危險物品信息發(fā)布管理規(guī)定》