DerMorphin Trifluoroacetate
| 中文名稱 | DerMorphin Trifluoroacetate |
|---|---|
| 中文同義詞 | 皮啡肽三氟乙酸鹽;化合物DERMORPHIN TFA |
| 英文名稱 | DerMorphin Trifluoroacetate |
| 英文同義詞 | DerMorphin Trifluoroacetic Acid Salt;DerMorphin Trifluoroacetate;Dermorphin TFA;MOR,nerve,spinal,wide-dynamic,neuron,ganglion,neuropathic,heptapeptide,inhibit,nervous,pain,Natural,Dermorphin,opioid,Opioid Receptor,skin,system,peripheral,mu-opioid,Dermorphin TFA,Inhibitor,ligation,amphibian |
| CAS號(hào) | 78331-26-7 |
| 分子式 | C42H51F3N8O12 |
| 分子量 | 916.91 |
| EINECS號(hào) | |
| 相關(guān)類別 | Amino Acids & Derivatives;Neurochemicals;Peptides;Amino Acids & Derivatives, Neurochemicals, Peptides |
| Mol文件 | 78331-26-7.mol |
| 結(jié)構(gòu)式 |  |
DerMorphin Trifluoroacetate 性質(zhì)
| 熔點(diǎn) | 157-162°C |
|---|---|
| 儲(chǔ)存條件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
Dermorphin TFA 是在兩棲類皮膚中發(fā)現(xiàn)的一種天然七肽 μ-阿片受體 (MOR) 激動(dòng)劑。Dermorphin 可用于抑制神經(jīng)痛。
μ-opioid receptor (MOR)
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO hMu , Dermorphin and DeNo displac the binding of [ 3 H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ 3 H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ 35 S] in a concentration dependent and saturable manner at the Mu receptor.