3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮
| 中文名稱 | 3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 |
|---|---|
| 中文同義詞 | 3-[二(4-甲氧基苯基)亞甲基]-1,3-二氫-2H-吲哚-2-酮;TAS-301游離態(tài);化合物TAS-301;TAS 301,平滑肌細(xì)胞遷移和增殖的抑制劑 |
| 英文名稱 | TAS-301 |
| 英文同義詞 | 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one;3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one;CS-1543;TAS 301.TAS301;TAS-301;TAS 301.TAS301;2H-Indol-2-one,3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-;Protein kinase C,inhibit,Inhibitor,TAS301,PKC,TAS-301 |
| CAS號 | 193620-69-8 |
| 分子式 | C23H19NO3 |
| 分子量 | 357.4 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑，天然產(chǎn)物;小分子抑制劑;Inhibitors |
| Mol文件 | 193620-69-8.mol |
| 結(jié)構(gòu)式 |  |
3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 性質(zhì)
| 儲存條件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | 二甲基亞砜：40 mg/毫升 |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
TAS-301是平滑肌細(xì)胞遷移和增殖的抑制劑，在大鼠頸動脈球囊損傷后抑制內(nèi)膜增厚。TAS-301 可抑制PDGF誘導(dǎo)的 PKC 激活。
| Target | Value |
|
PKC
() |
TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca 2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.
TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.
安全信息
| 安全說明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | S6424 | 3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 5mg | 877.31元 |
| 2023/03/20 | S6424 | 3-(雙(4-甲氧基苯基)亞甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 25mg | 2596.51元 |