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| | Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Basic information |
| | Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Chemical Properties |
| Melting point | 117-120℃ | | Boiling point | 117-120 °C(lit.) | | density | 1.174 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.5040(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 9.82±0.25(Predicted) | | form | clear liquid | | color | Colorless to Almost colorless | | Specific Gravity | 1.19 | | InChIKey | SJUXLKYJKQBZLM-UHFFFAOYSA-N | | CAS DataBase Reference | 1999-00-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29183000 |
| | Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | Reactant used as a precursor in:
- Condensation reactions with diamines via C-C bond cleavage for synthesis of benzimidazoles and perimidines for possible use as antimalarial treatments
- Base-promoted domino Michael addition / cyclization / elimination reactions for synthesis of hydroxybenzophenones
- Oxidative cross-coupling with indoles via dioxygen activation
- Cyclization of keto esters for synthesis of pyrones
- Lewis base catalyzed hydrosilylation for synthesis of α-acetoxy β-amino acid derivatives
- Conia-ene reactions for synthesis of methylenecyclopentane derivatives
| | General Description | Ethyl (4-fluorobenzoyl)acetate on condensation with benzofurazan oxide yields 2-(carboethoxy)-3-(4′-fluoro)phenylquinoxaline1,4-dioxide. |
| | Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Preparation Products And Raw materials |
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