成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

TYR-PRO-TRP-PHE-NH2

TYR-PRO-TRP-PHE-NH2

中文名稱TYR-PRO-TRP-PHE-NH2
中文同義詞內(nèi)嗎啡 1;內(nèi)嗎啡肽 1;內(nèi)嗎啡肽 1、ENDOMORPHIN 1;內(nèi)啡肽-1(醋酸鹽);ENDOMORPHIN-1,MU激動(dòng)劑
英文名稱ENDOMORPHIN-1
英文同義詞L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide;H-TYR-PRO-TRP-PHE-NH2;ENDOMORPHIN-1;ENDOMORPHIN-1 (HUMAN, BOVINE);TYR-PRO-TRP-PHE-NH2;YPWF-NH2;L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
CAS號(hào)189388-22-5
分子式C34H38N6O5
分子量610.7
EINECS號(hào)
相關(guān)類別生物活性小分子;細(xì)胞生物學(xué);多肽;細(xì)胞信號(hào)和神經(jīng)生物學(xué);SignalTransduction;Other Opioid Peptides;Other Opioid PeptidesPeptides for Cell Biology;Opioid receptor and opioid-like receptor;Peptide;Neuropeptides;Opioid Peptides
Mol文件189388-22-5.mol
結(jié)構(gòu)式TYR-PRO-TRP-PHE-NH2 結(jié)構(gòu)式

TYR-PRO-TRP-PHE-NH2 性質(zhì)

熔點(diǎn)144-146℃
沸點(diǎn)1052.8±65.0 °C(Predicted)
密度1.343±0.06 g/cm3(Predicted)
RTECS號(hào)SQ7316800
儲(chǔ)存條件−20°C
溶解度水中≥14.9 mg/mL; DMSO 中≥30.55 mg/mL;乙醇中≥47 mg/mL
酸度系數(shù)(pKa)9.86±0.15(Predicted)
形態(tài)固體
顏色白色至類白色
水溶解性Soluble in water
CAS 數(shù)據(jù)庫(kù)189388-22-5(CAS DataBase Reference)

TYR-PRO-TRP-PHE-NH2 用途與合成方法

Endomorphin 1,一種高度選擇性的高親和力μ-opioid受體激動(dòng)劑 , 對(duì)kappa3結(jié)合位點(diǎn)具有高親和力 ,Ki為 20 到 30 nM 之間。

Ki: 20-30 nM (kappa 3 opioid receptor)

Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2). The two Endomorphins display reasonable affinities for kappa 3 binding sites, with K i values between 20 and 30 nM. Endomorphin 1 and Endomorphin 2 compete both μ 1 and μ 2 receptor sites quite potently. Endomorphins have little appreciable affinity for either delta or kappa 1 binding sites, with K i values greater than 500 nM.

Both Endomorphin 1 and Endomorphin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. Endomorphin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than Endomorphin 2. The response of both agents are readily reversed by naloxone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both Endomorphins. Both Endomorphin 1 and Endomorphin 2 display a profile similar to morphine. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice.

安全信息

WGK Germany3

MSDS信息

提供商 語(yǔ)言
英文
更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-P0185TYR-PRO-TRP-PHE-NH2
Endomorphin 1
189388-22-55mg500元
2024/11/08HY-P0185TYR-PRO-TRP-PHE-NH2
Endomorphin 1
189388-22-510mM * 1mLin Water672元

TYR-PRO-TRP-PHE-NH2 上下游產(chǎn)品信息

"TYR-PRO-TRP-PHE-NH2"相關(guān)產(chǎn)品信息
主頁(yè) | 企業(yè)會(huì)員服務(wù) | 廣告業(yè)務(wù) | 聯(lián)系我們 | 舊版入口 | 中文MSDS | CAS Index | 常用化學(xué)品CAS列表 | 化工產(chǎn)品目錄 | 新產(chǎn)品列表 | 評(píng)選活動(dòng) | HS海關(guān)編碼 | MSDS查詢 | 化工站點(diǎn)

Copyright © 2016-2023 ChemicalBook 版權(quán)所有  京ICP備07040585號(hào)  京公海網(wǎng)安備11010802032676號(hào)  

互聯(lián)網(wǎng)增值電信業(yè)務(wù)經(jīng)營(yíng)許可證:京ICP證150597號(hào)  互聯(lián)網(wǎng)藥品信息服務(wù)資格證編號(hào)(京)-非經(jīng)營(yíng)性-2015-0073  信息系統(tǒng)安全等級(jí)保護(hù)備案證明(三級(jí))  營(yíng)業(yè)執(zhí)照公示

根據(jù)相關(guān)法律法規(guī)和本站規(guī)定,單位或個(gè)人購(gòu)買相關(guān)危險(xiǎn)物品應(yīng)取得有效的資質(zhì)、資格條件。
參考《應(yīng)急管理部等多部門關(guān)于加強(qiáng)互聯(lián)網(wǎng)銷售危險(xiǎn)化學(xué)品安全管理的通知 (應(yīng)急〔2022〕119號(hào))》《互聯(lián)網(wǎng)危險(xiǎn)物品信息發(fā)布管理規(guī)定》