化合物T7747
| 中文名稱 | 化合物T7747 |
|---|---|
| 中文同義詞 | 化合物T7747;化合物 DATELLIPTIUM CHLORIDE HYDROCHLORIDE |
| 英文名稱 | Datelliptium chloride hydrochloride |
| 英文同義詞 | Datelliptium chloride hydrochloride;antitumoral,Datelliptium chloride hydrochloride,DNA/RNA Synthesis,activity,Inhibitor,Ellipticine,hepatotoxicity,inhibit,Datelliptium chloride,antineoplastic |
| CAS號(hào) | 157000-76-5 |
| 分子式 | C23H28ClN3O |
| 分子量 | 397.95 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 157000-76-5.mol |
| 結(jié)構(gòu)式 |  |
化合物T7747 性質(zhì)
Datelliptium chloride hydrochloride 是一種由 Ellipticine (HY-15753) 衍生的 DNA 嵌合劑。Datelliptium chloride hydrochloride 在體內(nèi)對(duì)多種小鼠實(shí)體瘤有效。
Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210.
| Animal Model: | Mice, colon adenocarcinoma early staged disease model |
| Dosage: | 170 mg/kg |
| Administration: | Intravenous injection, for 12 days |
| Result: | Highly active against colon adenocarcinoma. |