[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
生物活性靶點(diǎn)體外研究 用途與合成方法 MSDS [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息
| 中文名稱 | [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |
|---|---|
| 中文同義詞 | (4-(雙(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基異惡唑-3-基)甲酮;化合物ML-210;(4-(雙(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基異噁唑-3-基)甲酮;ML 210,殺死突變的表達(dá)HRAS的細(xì)胞 |
| 英文名稱 | [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone |
| 英文同義詞 | [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone;CID 49766530;ML 210;[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone;ML 210 - CID 49766530;Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-;ML 210 >=98% (HPLC);(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone |
| CAS號(hào) | 1360705-96-9 |
| 分子式 | C22H20Cl2N4O4 |
| 分子量 | 475.32 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1360705-96-9.mol |
| 結(jié)構(gòu)式 | ![[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone 結(jié)構(gòu)式](CAS/20180629/GIF/1360705-96-9.gif) |
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone 性質(zhì)
| 沸點(diǎn) | 644.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.415±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 溶于 DMSO（高達(dá) 30 mg/ml） |
| 酸度系數(shù)(pKa) | 4.69±0.10(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 穩(wěn)定性 | 可在-20°C的DMSO中的溶液下儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。 |
ML-210 (CID 49766530)是一種選擇性的 glutathione peroxidase 4 (GPX4) 的共價(jià)抑制劑，其EC50值為0.04 μM，可誘導(dǎo)鐵死亡。ML-210 可以選擇性地殺死誘導(dǎo)表達(dá)突變型 RAS 的細(xì)胞，并具有抗癌活性。
| Target | Value |
|
RAS
() | |
|
GPX4
(Cell-free assay) | 0.04 μM(EC50) |
ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4.
ML-210 has
IC
50
s of 71 nM, 272 nM and 107nM for BJeLR (HRAS
V12
), BJeH-LT (without HRAS
V12
) and DRD cell lines, respectively.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-100003 | ML-210 | 1 mg | 409元 | |
| 2024/11/08 | S0788 | [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML 210 | 1360705-96-9 | 2mg | 647.01元 |