- W-13 hydrochloride
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- $30.00 / 1mg
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2024-11-12
- CAS:88519-57-7
- Min. Order:
- Purity: 98.51%
- Supply Ability: 10g
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| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Basic information |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Chemical Properties |
Melting point | 241-243°C | storage temp. | room temp | solubility | H2O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4°C.soluble | form | powder | color | white | CAS DataBase Reference | 88519-57-7(CAS DataBase Reference) |
Safety Statements | 22-24/25 | WGK Germany | 3 | HS Code | 2935.90.9500 |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Usage And Synthesis |
Description | W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities. | Chemical Properties | Beige Solid | Uses | Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities. | Uses | W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities. | Definition | ChEBI: N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride is a hydrochloride salt prepared from equimolar amounts of N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide and hydrogen chloride. It contains a N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide(1+). | Biological Activity | Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells. | Biochem/physiol Actions | W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells. | storage | Store at RT |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials |
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