- Benzydamine hydrochloride
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- $0.00 / 1Kg/Bag
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2024-11-04
- CAS:132-69-4
- Min. Order: 1KG
- Purity: 99.0%-101.0%
- Supply Ability: 1000 KGS
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| | Benzydamine hydrochloride Basic information |
| | Benzydamine hydrochloride Chemical Properties |
| Melting point | 147-153°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble in water, ethanol, chloroform, n-butanol or DMSO
/n | | Merck | 14,1122 | | InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N | | CAS DataBase Reference | 132-69-4(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | NK7875000 | | HS Code | 2933.99.8290 | | Toxicity | LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini) |
| | Benzydamine hydrochloride Usage And Synthesis |
| Description | Benzydamine hydrochloride is a non-steroidal antiinflammatory
drug used both topically and systemically.
It has been reported as a sensitizer and a
photosensitizer and caused occupational contact dermatitis
in a nurse. | | Chemical Properties | Off-White Solid | | Originator | Tantum,Angelini | | Uses | Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis. | | Uses | A nonsteroidal anti-inflammatory with local anesthetic properties. | | Uses | anticholinergic | | Uses | A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties. | | Definition | ChEBI: Benzydamine hydrochloride is a member of indazoles. | | Manufacturing Process | To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt. | | Brand name | Tantum (Angelini Francesco, Italy). | | Therapeutic Function | Analgesic, Antiinflammatory, Antipyretic | | Contact allergens | It is a nonsteroidal anti-inflammatory drug used both
topically and systemically. It has been reported as a
sensitizer and a photosensitizer. | | Side effects | The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration. | | Safety Profile | Poison by
intraperitoneal, subcutaneous, and
intravenous routes. Moderately toxic by
ingestion. An experimental teratogen. Other
experimental animal reproductive effects.
An eye irritant. A nonsteroidal antiinflammatory
analgesic. When heated to
decomposition it emits very toxic fumes of
HCl and NOx. |
| | Benzydamine hydrochloride Preparation Products And Raw materials |
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