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ChemicalBook >> CAS DataBase List >> Tacrolimus

Tacrolimus

Tacrolimus price.
  • $31 - $1320
  • Product name: Tacrolimus
  • CAS: 104987-11-3
  • MF: C44H69NO12
  • MW: 804.02
  • EINECS:1308068-626-2
  • MDL Number:MFCD00869853
  • Synonyms:(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s* ;,19s*,26ar*))- ;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1 ;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L 679934;FK-506：FR-900506;Fujimycin Prozraf;Tacrolimus,micronisedandpharmagrade
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  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
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  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
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  • 5MG
  • 10mg
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  • 250mg
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  • 10mM(in 1mL DMSO)
  • 1g
  • 1mL
  • 2g
  • 5g
  • ManufacturerAK Scientific
  • Product numberJ40076
  • Product descriptionTacrolimus
  • Packaging10mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63571
  • Product descriptionTacrolimus 99+%
  • Packaging50mg
  • Price$206
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63571
  • Product descriptionTacrolimus 99+%
  • Packaging100mg
  • Price$305
  • Updated2023-06-20
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  • ManufacturerAlfa Aesar
  • Product numberJ63571
  • Product descriptionTacrolimus, 99+%
  • Packaging500mg
  • Price$790
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA335856
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging50mg
  • Price$31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA335856
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging100mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA335856
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging250mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA335856
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging1g
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA335856
  • Product description(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+%
  • Packaging5g
  • Price$654
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045714
  • Product descriptionTACROLIMUS 99.00%
  • Packaging5MG
  • Price$534
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045714
  • Product descriptionTACROLIMUS 99.00%
  • Packaging10MG
  • Price$686.9
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045714
  • Product descriptionTACROLIMUS 99.00%
  • Packaging25MG
  • Price$707.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2143
  • Product descriptionTacrolimus(FK506)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2143
  • Product descriptionTacrolimus(FK506)
  • Packaging50mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2143
  • Product descriptionTacrolimus(FK506)
  • Packaging100mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2143
  • Product descriptionTacrolimus(FK506)
  • Packaging200mg
  • Price$180
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J40076 Tacrolimus 10mg $56 2021-12-16 Buy
Alfa Aesar J63571 Tacrolimus 99+% 50mg $206 2023-06-20 Buy
Alfa Aesar J63571 Tacrolimus 99+% 100mg $305 2023-06-20 Buy
Alfa Aesar J63571 Tacrolimus, 99+% 500mg $790 2023-06-20 Buy
Ambeed A335856 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 50mg $31 2021-12-16 Buy
Ambeed A335856 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 100mg $52 2021-12-16 Buy
Ambeed A335856 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 250mg $75 2021-12-16 Buy
Ambeed A335856 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 1g $192 2021-12-16 Buy
Ambeed A335856 (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone 98+% 5g $654 2021-12-16 Buy
American Custom Chemicals Corporation API0045714 TACROLIMUS 99.00% 5MG $534 2021-12-16 Buy
American Custom Chemicals Corporation API0045714 TACROLIMUS 99.00% 10MG $686.9 2021-12-16 Buy
American Custom Chemicals Corporation API0045714 TACROLIMUS 99.00% 25MG $707.9 2021-12-16 Buy
ApexBio Technology B2143 Tacrolimus(FK506) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology B2143 Tacrolimus(FK506) 50mg $65 2021-12-16 Buy
ApexBio Technology B2143 Tacrolimus(FK506) 100mg $120 2021-12-16 Buy
ApexBio Technology B2143 Tacrolimus(FK506) 200mg $180 2021-12-16 Buy

Properties

Melting point :113-115°C
Boiling point :871.7±75.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: >3 mg/mL
form :solid
pka :9.97±0.70(Predicted)
color :white
optical activity :+62.223 (CHCl3)
Water Solubility :Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
BCS Class :2
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey :QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS DataBase Reference :104987-11-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. It is also used in the treatment of other T cell-mediated diseases such as eczema, Kimura's disease and Cushing's syndrome. Further, it is used as a research tool in chemically induced dimerization applications. In addition, it is used in liver transplantation and to suppress the inflammation in ulcerative cells. In dermatology, it is used as an ointment to treat eczema especially atopic dermatitis.

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