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ChemicalBook >> CAS DataBase List >> TYRPHOSTIN AG 879

TYRPHOSTIN AG 879

TYRPHOSTIN AG 879 price.
  • $6 - $1900
  • Product name: TYRPHOSTIN AG 879
  • CAS: 148741-30-4
  • MF: C18H24N2OS
  • MW: 316.46
  • EINECS:
  • MDL Number:MFCD00236450
  • Synonyms:2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (E)-;AG-879 100MG;TYRPHOSTIN 879;TYRPHOSTIN AG 879;(3,5-DI-T-BUTYL-4-HYDROXYBENZYLIDENE)THIOCYANOACETAMIDE;AG 879;ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE;ALPHA-CYANO-(3,5-DI-TERT-BUTYL-4-HYDROXY)THIOCINNAMAMIDE
32 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2775AH
  • Product descriptionTyrphostin AG 879
  • Packaging100mg
  • Price$778
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging1mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging5mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging10mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging25mg
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging50mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging100mg
  • Price$71
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging250mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA153685
  • Product descriptionTyrphostin AG 879 95+%
  • Packaging1g
  • Price$312
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000515
  • Product descriptionTYRPHOSTIN AG 879 95.00%
  • Packaging5MG
  • Price$689.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000515
  • Product descriptionTYRPHOSTIN AG 879 95.00%
  • Packaging25MG
  • Price$999.31
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1544
  • Product descriptionTyrphostin AG 879
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1544
  • Product descriptionTyrphostin AG 879
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10793
  • Product descriptionAG 879 ≥95%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10793
  • Product descriptionAG 879 ≥95%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10793
  • Product descriptionAG 879 ≥95%
  • Packaging25mg
  • Price$255
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2775AH Tyrphostin AG 879 100mg $778 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 1mg $6 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 5mg $13 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 10mg $19 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 25mg $32 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 50mg $48 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 100mg $71 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 250mg $120 2021-12-16 Buy
Ambeed A153685 Tyrphostin AG 879 95+% 1g $312 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000515 TYRPHOSTIN AG 879 95.00% 5MG $689.25 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000515 TYRPHOSTIN AG 879 95.00% 25MG $999.31 2021-12-16 Buy
ApexBio Technology B1544 Tyrphostin AG 879 5mg $50 2021-12-16 Buy
ApexBio Technology B1544 Tyrphostin AG 879 10mg $80 2021-12-16 Buy
Cayman Chemical 10793 AG 879 ≥95% 5mg $68 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 10mg $109 2024-03-01 Buy
Cayman Chemical 10793 AG 879 ≥95% 25mg $255 2024-03-01 Buy

Properties

Boiling point :432.7±55.0 °C(Predicted)
Density :1.127±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: at 26 mg/mlsoluble
pka :9.63±0.70(Predicted)
form :Orange-yellow solid
color :Yellow
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors. AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 μM) in schwannoma cells.

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