TW-37
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- $32 - $17600
- Product name: TW-37
- CAS: 877877-35-5
- MF: C33H35NO6S
- MW: 573.7
- EINECS:-0
- MDL Number:MFCD17010275
- Synonyms:TW-37;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide;N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide TW-37;Bcl-2 Inhibitor N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide;CS-299
26 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Crysdot
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 50
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging1mg
- Price$32
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging5mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging50mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging100mg
- Price$583
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252493
- Product descriptionN-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+%
- Packaging250mg
- Price$1166
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000892
- Product descriptionTW-37 95.00%
- Packaging1G
- Price$17600
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000892
- Product descriptionTW-37 95.00%
- Packaging50MG
- Price$1260
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000892
- Product descriptionTW-37 95.00%
- Packaging10MG
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4234
- Product descriptionTW-37
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180746
- Product descriptiontw-37 >98%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180746
- Product descriptiontw-37 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180746
- Product descriptiontw-37 >98%
- Packaging1g
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number20999
- Product descriptionTW-37 ≥98%
- Packaging5mg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20999
- Product descriptionTW-37 ≥98%
- Packaging10mg
- Price$185
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20999
- Product descriptionTW-37 ≥98%
- Packaging25mg
- Price$380
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 1mg | $32 | 2021-12-16 | Buy |
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 5mg | $54 | 2021-12-16 | Buy |
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 10mg | $90 | 2021-12-16 | Buy |
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 50mg | $333 | 2021-12-16 | Buy |
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 100mg | $583 | 2021-12-16 | Buy |
| Ambeed | A252493 | N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 98+% | 250mg | $1166 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000892 | TW-37 95.00% | 1G | $17600 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000892 | TW-37 95.00% | 50MG | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000892 | TW-37 95.00% | 10MG | $600 | 2021-12-16 | Buy |
| ApexBio Technology | A4234 | TW-37 | 50mg | $470 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180746 | tw-37 >98% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180746 | tw-37 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180746 | tw-37 >98% | 1g | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 20999 | TW-37 ≥98% | 5mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 20999 | TW-37 ≥98% | 10mg | $185 | 2024-03-01 | Buy |
| Cayman Chemical | 20999 | TW-37 ≥98% | 25mg | $380 | 2024-03-01 | Buy |
Properties
Boiling point :723.7±60.0 °C(Predicted)
Density :1.280
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
form :A crystalline solid
pka :7.86±0.50(Predicted)
color :White to off-white
Density :1.280
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
form :A crystalline solid
pka :7.86±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.Related product price
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