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ChemicalBook >> CAS DataBase List >> Podophyllotoxin

Podophyllotoxin

Podophyllotoxin price.
  • $9 - $1720
  • Product name: Podophyllotoxin
  • CAS: 518-28-5
  • MF: C22H22O8
  • MW: 414.41
  • EINECS:208-250-4
  • MDL Number:MFCD00075290
  • Synonyms:Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-;Podophyllotoxin ,98%;(5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one;Podophyllotoxin,95%;trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;PODOPHYLLIN(RG);5,8,8a,9-tetrahydro-9-hydroxy-5- (3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one;(5R,5AR,8AR,9R)-9-HYDROXY-5-(3,4,5-TRIMETHOXY-PHENYL)-5,8,8A,9-TETRAHYDRO-5AH-FURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6-ONE
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Brand
  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • JR MediChem
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Oakwood
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1G
  • 1000mg
  • 2.5g
  • 5g
  • 10g
  • 25g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0049-M100
  • Product descriptionPodophyllotoxin ≥98%(HPLC)
  • Packaging100mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberAPI-1441
  • Product descriptionPodophyllotoxin 98%
  • Packaging5g
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ91208
  • Product descriptionPodophyllotoxin
  • Packaging10g
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10533
  • Product descriptionPodophyllotoxin
  • Packaging100mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF719
  • Product descriptionPodophyllotoxin
  • Packaging10g
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberTOX0000324
  • Product descriptionPODOPHYLLOTOXIN 95.00%
  • Packaging1G
  • Price$852.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberTOX0000324
  • Product descriptionPODOPHYLLOTOXIN 95.00%
  • Packaging5G
  • Price$1548.26
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1790
  • Product descriptionPodophyllotoxin
  • Packaging20mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN1790
  • Product descriptionPodophyllotoxin
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS022722
  • Product description(5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98%
  • Packaging100mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS022722
  • Product description(5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98%
  • Packaging250mg
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS022722
  • Product description(5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98%
  • Packaging1g
  • Price$25
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN99168
  • Product descriptionPodophyllotoxin ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2680
  • Product descriptionPodophyllotoxin
  • Packaging25mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2680
  • Product descriptionPodophyllotoxin
  • Packaging100mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2680
  • Product descriptionPodophyllotoxin
  • Packaging1g
  • Price$39
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0049-M100 Podophyllotoxin ≥98%(HPLC) 100mg $40 2021-12-16 Buy
AHH API-1441 Podophyllotoxin 98% 5g $800 2021-12-16 Buy
AK Scientific J91208 Podophyllotoxin 10g $90 2021-12-16 Buy
AK Scientific J10533 Podophyllotoxin 100mg $95 2021-12-16 Buy
AK Scientific F719 Podophyllotoxin 10g $121 2021-12-16 Buy
American Custom Chemicals Corporation TOX0000324 PODOPHYLLOTOXIN 95.00% 1G $852.55 2021-12-16 Buy
American Custom Chemicals Corporation TOX0000324 PODOPHYLLOTOXIN 95.00% 5G $1548.26 2021-12-16 Buy
ApexBio Technology N1790 Podophyllotoxin 20mg $40 2021-12-16 Buy
ApexBio Technology N1790 Podophyllotoxin 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Arctom AS022722 (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98% 100mg $9 2021-12-16 Buy
Arctom AS022722 (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98% 250mg $13 2021-12-16 Buy
Arctom AS022722 (5R,5aR,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one ≥98% 1g $25 2021-12-16 Buy
Arctom CFN99168 Podophyllotoxin ≥98% 20mg $30 2021-12-16 Buy
AvaChem 2680 Podophyllotoxin 25mg $25 2021-12-16 Buy
AvaChem 2680 Podophyllotoxin 100mg $29 2021-12-16 Buy
AvaChem 2680 Podophyllotoxin 1g $39 2021-12-16 Buy

Properties

Melting point :183-184 °C (lit.)
alpha :-110.7 º (c=1, CHCl3)
Boiling point :453.31°C (rough estimate)
Density :1.2649 (rough estimate)
refractive index :1.4480 (estimate)
storage temp. :2-8°C
solubility :DMSO:15.0(Max Conc. mg/mL);36.2(Max Conc. mM)
form :Powder
pka :13.26±0.40(Predicted)
color :White to off-white
optical activity :[α]/D 131±2°, c = 1 in chloroform
Merck :13,7628
BRN :99163
Stability :Very Hygroscopic
InChIKey :YJGVMLPVUAXIQN-XVVDYKMHSA-N
LogP :2.010
CAS DataBase Reference :518-28-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide , teniposide , and etopophos.

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